ANTI-beta(2)-GLYCOPROTEIN I ANTIBODIES ARE HIGHLY PREVALENT IN A LARGE NUMBER OF BRAZILIAN LEPROSY PATIENTS

Show simple item record

dc.contributor.author Ribeiro, Sandra Lucia Euzebio [UNIFESP]
dc.contributor.author Pereira, Helena Lúcia Alves [UNIFESP]
dc.contributor.author Silva, Neusa Pereira da [UNIFESP]
dc.contributor.author Souza, Alexandre Wagner Silva de [UNIFESP]
dc.contributor.author Sato, Emilia Inoue [UNIFESP]
dc.date.accessioned 2018-06-15T12:47:30Z
dc.date.available 2018-06-15T12:47:30Z
dc.date.issued 2011-01-01
dc.identifier http://www.actareumatologica.pt/article_download.php?id=648
dc.identifier.citation Acta Reumatologica Portuguesa. Alges: Medfarma-edicoes Medicas, Lda, v. 36, n. 1, p. 30-37, 2011.
dc.identifier.issn 0303-464X
dc.identifier.uri http://repositorio.unifesp.br/11600/42090
dc.description.abstract Objectives: To determine the prevalence of anticardiolipin (aCL) and anti-beta(2)-glycoprotein I (anti-beta(2)GPI) antibodies in leprosy patients, during and after specific multidrug therapy (MDT), and to evaluate a possible association between these antibodies and some clinical characteristics of leprosy, including clinical forms, reactional episodes and treatment.Methods: The study included 158 leprosy patients, 129 gender-and-age matched healthy individuals, and 38 women with primary antiphospholipid syndrome (APS). Clinical and demographic characteristic of leprosy patients were collected, and serum samples, obtained from all participants, were kept frozen at - 20 degrees C. Antibodies were measured either by an in house-developed ELISA (aCL) or by a commercial ELISA (anti-beta(2)GPI).Results and Conclusions: Increased levels of aCL and anti-beta(2)GPI antibodies were found in leprosy patients and in the APS group, however, in contrast to APS, the predominant isotype in leprosy was IgM. The frequency of aCL and anti-beta(2)GPI antibodies was significantly higher in leprosy patients than in healthy individuals (15.8% vs. 3.1%; p < 0.01; 46.2% vs. 9.4%, p < 0.01), respectively. The lepromatous form predominated among aCL positive leprosy patients (p < 0.01). There was no difference in aCL and anti-beta(2)GPI positivity between leprosy patients taking MDT and those completed MDT as cured. Furthermore the duration of discharged period (period between discharge from MDT and the realization of the study) had no effect on anti-beta(2)GPI positivity, and a slight increase in aCL positivity was observed in patients with longer follow up periods (p=0.04), suggesting that the presence of antiphospholipid antibodies (aPL) was not a transient phenomenon. Although aPL in leprosy were frequent and beta(2)GPI-dependent as those found in APS, IgM was the predominant isotype, and there was no association with thrombosis or other APS manifestations. en
dc.format.extent 30-37
dc.language.iso eng
dc.publisher Medfarma-edicoes Medicas, Lda
dc.relation.ispartof Acta Reumatologica Portuguesa
dc.rights Acesso aberto
dc.subject Leprosy en
dc.subject Anti-beta(2)-glycoprotein I antibodies en
dc.subject Antiphospholipid antibodies en
dc.subject Anticardiolipin antibodies en
dc.subject Antiphospholipid syndrome en
dc.title ANTI-beta(2)-GLYCOPROTEIN I ANTIBODIES ARE HIGHLY PREVALENT IN A LARGE NUMBER OF BRAZILIAN LEPROSY PATIENTS en
dc.type Artigo
dc.contributor.institution Univ Fed Amazonas
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Amazonas, Div Rheumatol, Manaus, Amazonas, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Div Rheumatol, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Div Rheumatol, Sao Paulo, Brazil
dc.identifier.file WOS000288828700006.pdf
dc.description.source Web of Science
dc.identifier.wos WOS:000288828700006



File

Name: WOS000288828700006.pdf
Size: 216.6Kb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account