Placental transfer of Haemophilus influenzae type b antibodies in malnourished pregnant women

Placental transfer of Haemophilus influenzae type b antibodies in malnourished pregnant women

Author Cavalcante, Rejane Silva Autor UNIFESP Google Scholar
Kopelman, Benjamin Israel Autor UNIFESP Google Scholar
Costa-Carvalho, Beatriz Tavares Autor UNIFESP Google Scholar
Institution University State of Pará Department of Integrated Health
Universidade Federal de São Paulo (UNIFESP)
Abstract This study evaluated the vaccination response to Haemophilus influenzae type b (Hib) in malnourished pregnant women (MN), cord blood (CB) and in infants at two and six months of age for comparison with a control group (C). Twenty-eight malnourished pregnant women and 29 pregnant controls were immunized with conjugated Act-HIB® in the third trimester of pregnancy. Blood samples were collected from all before the immunization, during labor (post immunization), and from CB. All infants were immunized with Hib vaccine according to normal vaccine schedule and sera were collected at two and six months of age. Antibody levels to polyribosylribitol phosphate (PRP) were similar for both groups. Preimmunization: MN 1.94 µg/mL, C 1.68 µg/mL; post-vaccination: MN 18.53 µg/mL and C 17.55 µg/mL; in CB from MN 14.46 µg/mL and from C 17.04 µg/mL. Infants from MN and C mothers presented respectively at two months: 5.18 µg/mL and 8.60 µg/mL and at six months: MN 3.42 µg/mL and C 2.18 µg/mL. Antibody levels were similar in both groups studied (p = 0.485), however the vertical transmission rate was 14% lower in the MN pregnant group. Levels of antibodies > 0.15 µg/mL were found in all newborns from the MN pregnant group. Pregnant MN presented an immunological response to Hib vaccine similar to group C, however, vertical transmission rate of antibodies to PRP in the MN pregnant group was 14% lower than that in C, suggesting a less efficient passage of antibodies within this group.
Keywords Pregnant women
Haemophilus influenzae type b
passive immunization
immunoglobulin G
Language English
Date 2008-02-01
Published in Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 12, n. 1, p. 47-51, 2008.
ISSN 1413-8670 (Sherpa/Romeo, impact factor)
Publisher Brazilian Society of Infectious Diseases
Extent 47-51
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000257126000011
SciELO ID S1413-86702008000100011 (statistics in SciELO)

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