Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide

Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide

Author Fernandes, Tania Rita Moreno de Oliveira Autor UNIFESP Google Scholar
Santos, Itamar Autor UNIFESP Google Scholar
Korinsfky, Juliana Pedrosa Google Scholar
Silva, Benedyto Savio de Lima e Autor UNIFESP Google Scholar
Carvalho, Luis Otavio Google Scholar
Plapler, Helio Autor UNIFESP Google Scholar
Institution Fed Univ Sao Francisco Valley UNIVASF
Fundacao Univ Fed Vale Sao Francisco
Oswaldo Cruz Inst Fdn FioCruz
Universidade Federal de São Paulo (UNIFESP)
Abstract PURPOSE: To study the possible potentiation of the carcinogenic effects of ultraviolet radiation associated with an organophosphate pesticide.METHODS: Forty Wistar rats were assigned into four groups (n=10 each) randomized according to the procedures: group A received only UVR-B radiation; group B, UVR-B for eight weeks followed by a seven week period of pesticide exposure; group C, UVR-B + pesticide concomitantly: group D, only pesticide application. At the end of the fifth, tenth and fifteenth weeks the animals were photographed. Skin biopsy and histopathological study with Hematoxylin-Eosin were done on the fifteenth week. Statistical analysis with Fisher's and Sign (unilateral) tests, 5% value for significance.RESULTS: Macroscopic lesions in the group A evolved from the erythema to erythema + desquamation. The groups B and C, with the association of two carcinogens, and group D presented evolution to keratosis, with higher incidence in group D. The histology showed a significant increase in the severity of injuries when the UVR-B and the pesticide were applied simultaneously, leading to cellular atypia.CONCLUSIONS: Concurrent association of UVR-B to organophosphate pesticide produced more severe lesions microscopically, although this has not been so apparent macroscopically. In daily practice the clinical evaluation should be complemented with laboratory evaluation.
Keywords Epidermis
Solar Radiation
Skin Neoplasms
Organophosphates
Rats
Language English
Date 2014-01-01
Published in Acta Cirurgica Brasileira. Sao Paulo: Acta Cirurgica Brasileira, v. 29, n. 1, p. 7-15, 2014.
ISSN 0102-8650 (Sherpa/Romeo, impact factor)
Publisher Acta Cirurgica Brasileira
Extent 7-15
Origin http://dx.doi.org/10.1590/S0102-86502014000100002
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000330868700002
SciELO ID S0102-86502014000100002 (statistics in SciELO)
URI http://repositorio.unifesp.br/11600/41986

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