Adhesion prevention in reabsorbable polyethylene glycol hydrogel (Coseal (R)) coated polypropylene mesh in rabbits

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dc.contributor.author Quinino, Reynaldo Martins e [UNIFESP]
dc.contributor.author Araujo-Filho, Irami
dc.contributor.author Lima, Francisco Piganataro
dc.contributor.author Barbosa, Andre Luis Costa
dc.contributor.author Maia, Tatiana de Carvalho
dc.contributor.author Goldenberg, Alberto [UNIFESP]
dc.date.accessioned 2018-06-15T11:14:56Z
dc.date.available 2018-06-15T11:14:56Z
dc.date.issued 2013-12-01
dc.identifier http://dx.doi.org/10.1590/S0102-86502013001200001
dc.identifier.citation Acta Cirurgica Brasileira. Sao Paulo: Acta Cirurgica Brasileira, v. 28, n. 12, p. 807-814, 2013.
dc.identifier.issn 0102-8650
dc.identifier.uri http://repositorio.unifesp.br/11600/41983
dc.description.abstract PURPOSE: To evaluate of postoperative adhesion prevention and inflammatory response to polypropylene mesh, coated with reabsorbable hydrogel of polyethylene glycol (Coseal (R)) in contact with small bowel in an experimental model in rabbits.METHODS: Twenty female rabbits underwent laparotomy to implant two polypropylene meshes, 2x1cm, in the right and left flanks. The right mesh was protected with Coseal (R) spray (Group 1) and the left mesh received no treatment after implantation (Group 2). Thirty days after implantation, the rabbits underwent laparoscopy for adhesion analysis; the prosthesis were removed en bloc with the adjacent tissue for microscopic analysis of inflammation. Statistical analysis used the Mann-Whitney test.RESULTS: There was adhesion formation in five meshes (36%) from Group 1 and in 14 meshes (100%) from Group 2, with statistical significance (p<0.01). There were no differences in the inflammatory response, fibrosis, foreign body reaction, presence of collagen and type of inflammatory cells between the two groups.CONCLUSION: Polypropylene mesh coated with Coseal (R) showed a significantly lower rate of adhesion formation when compared with uncoated meshes, without interfering with inflammatory response. en
dc.format.extent 807-814
dc.language.iso eng
dc.publisher Acta Cirurgica Brasileira
dc.relation.ispartof Acta Cirurgica Brasileira
dc.rights Acesso aberto
dc.subject Tissue Adhesions en
dc.subject Polyethylene Glycols en
dc.subject Polypropylenes en
dc.subject Rabbits en
dc.title Adhesion prevention in reabsorbable polyethylene glycol hydrogel (Coseal (R)) coated polypropylene mesh in rabbits en
dc.type Artigo
dc.contributor.institution Rio Grande do Norte Fed Univ UFRN
dc.contributor.institution UFRN
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Rio Grande do Norte Fed Univ UFRN, Postgrad Program Interdisciplinary Surg Sci, BR-59072970 Natal, RN, Brazil
dc.description.affiliation Rio Grande do Norte Fed Univ UFRN, Integrated Med Dept, BR-59072970 Natal, RN, Brazil
dc.description.affiliation UFRN, Dept Surg, Rio Grande Do Norte, Brazil
dc.description.affiliation UFRN, Dept Pathol, Rio Grande Do Norte, Brazil
dc.description.affiliation UFRN, Onofre Lopes Univ Hosp, Rio Grande Do Norte, Brazil
dc.description.affiliation Sao Paulo Fed Univ UNIFESP, Dept Surg, Surg Gastroenterol Div, Sao Paulo, Brazil
dc.description.affiliationUnifesp Sao Paulo Fed Univ UNIFESP, Dept Surg, Surg Gastroenterol Div, Sao Paulo, Brazil
dc.identifier.file S0102-86502013001200001.pdf
dc.identifier.scielo S0102-86502013001200001
dc.identifier.doi 10.1590/S0102-86502013001200001
dc.description.source Web of Science
dc.identifier.wos WOS:000328649900001



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