Influence of cyclosporine A on mucociliary system after lung transplantation in rats

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dc.contributor.author Xavier, Alexandre Martins [UNIFESP]
dc.contributor.author Pego-Fernandes, Paulo Manuel
dc.contributor.author Correia, Aristides Tadeu
dc.contributor.author Pazetti, Rogerio
dc.contributor.author Monteiro, Rosangela
dc.contributor.author Canzian, Mauro [UNIFESP]
dc.contributor.author Jatene, Fabio Biscegli
dc.date.accessioned 2018-06-15T11:14:55Z
dc.date.available 2018-06-15T11:14:55Z
dc.date.issued 2007-11-01
dc.identifier http://dx.doi.org/10.1590/S0102-86502007000600009
dc.identifier.citation Acta Cirurgica Brasileira. Sao Paulo: Acta Cirurgica Brasileira, v. 22, n. 6, p. 465-469, 2007.
dc.identifier.issn 0102-8650
dc.identifier.uri http://repositorio.unifesp.br/11600/41975
dc.description.abstract Purpose: To investigate the function of the bronchial mucociliary system in transplanted rat lungs with and without the influence of immunosuppression. Methods: Thirty-six rats underwent single-lung transplantation and were divided into two groups, one of which received cyclosporine treatment, and the control group which did not. Cyclosporine was administered subcutaneously in doses of 10 mg/kg daily. The rats were sacrificed 2, 15 or 30 days after transplantation. In situ bronchial mucociliary transport (MCT) and ciliary beat frequency (CBF) were determined proximal and distal to the bronchial anastomosis. Results: Significant progressive improvement on MCT, proximal and distal to the anastomotic site, was also found in the cyclosporine-treated group at 15 and 30 days (p<0.01). No significant change in MCT was found in the control group. CBF behavior in the two groups. Histological analysis showed that rejection was significantly higher in the control group (p<0.05). Conclusion: Cyclosporine has a positive influence on bronchial mucociliary transport but not on CBF due to the effect of the rejection mechanism. en
dc.format.extent 465-469
dc.language.iso eng
dc.publisher Acta Cirurgica Brasileira
dc.relation.ispartof Acta Cirurgica Brasileira
dc.rights Acesso aberto
dc.subject lung transplantation en
dc.subject cyclosporine en
dc.subject immunosuppression en
dc.subject mucociliary clearance en
dc.subject rats en
dc.title Influence of cyclosporine A on mucociliary system after lung transplantation in rats en
dc.title.alternative Influência da ciclosporina A sobre o sistema mucociliar após-transplante pulmonar em ratos pt
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Univ Fed Sao Paulo, Dept Surg, Thorac Surg Div, Sao Paulo, Brazil
dc.description.affiliation Univ Sao Paulo, Sch Med, Dept Cardiopneumol, Thorac Surg Div, BR-05508 Sao Paulo, Brazil
dc.description.affiliation Univ Sao Paulo, Sch Med, Lab Thorac Surg Res, BR-05508 Sao Paulo, Brazil
dc.description.affiliation Univ Sao Paulo, Sch Med, Dept Cardiopneumol, Thorac Surg Div,InCor,Clin Hosp, BR-05508 Sao Paulo, Brazil
dc.description.affiliation Univ Sao Paulo, Sch Med, Pathol Lab, InCor,Clin Hosp, BR-05508 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Surg, Thorac Surg Div, Sao Paulo, Brazil
dc.identifier.file S0102-86502007000600009.pdf
dc.identifier.scielo S0102-86502007000600009
dc.identifier.doi 10.1590/S0102-86502007000600009
dc.description.source Web of Science
dc.identifier.wos WOS:000258573500009



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