Influence of cyclosporine A on mucociliary system after lung transplantation in rats

Influence of cyclosporine A on mucociliary system after lung transplantation in rats

Alternative title Influência da ciclosporina A sobre o sistema mucociliar após-transplante pulmonar em ratos
Author Xavier, Alexandre Martins Autor UNIFESP Google Scholar
Pego-Fernandes, Paulo Manuel Google Scholar
Correia, Aristides Tadeu Google Scholar
Pazetti, Rogerio Google Scholar
Monteiro, Rosangela Google Scholar
Canzian, Mauro Autor UNIFESP Google Scholar
Jatene, Fabio Biscegli Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Purpose: To investigate the function of the bronchial mucociliary system in transplanted rat lungs with and without the influence of immunosuppression. Methods: Thirty-six rats underwent single-lung transplantation and were divided into two groups, one of which received cyclosporine treatment, and the control group which did not. Cyclosporine was administered subcutaneously in doses of 10 mg/kg daily. The rats were sacrificed 2, 15 or 30 days after transplantation. In situ bronchial mucociliary transport (MCT) and ciliary beat frequency (CBF) were determined proximal and distal to the bronchial anastomosis. Results: Significant progressive improvement on MCT, proximal and distal to the anastomotic site, was also found in the cyclosporine-treated group at 15 and 30 days (p<0.01). No significant change in MCT was found in the control group. CBF behavior in the two groups. Histological analysis showed that rejection was significantly higher in the control group (p<0.05). Conclusion: Cyclosporine has a positive influence on bronchial mucociliary transport but not on CBF due to the effect of the rejection mechanism.
Keywords lung transplantation
cyclosporine
immunosuppression
mucociliary clearance
rats
Language English
Date 2007-11-01
Published in Acta Cirurgica Brasileira. Sao Paulo: Acta Cirurgica Brasileira, v. 22, n. 6, p. 465-469, 2007.
ISSN 0102-8650 (Sherpa/Romeo, impact factor)
Publisher Acta Cirurgica Brasileira
Extent 465-469
Origin http://dx.doi.org/10.1590/S0102-86502007000600009
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000258573500009
SciELO ID S0102-86502007000600009 (statistics in SciELO)
URI http://repositorio.unifesp.br/11600/41975

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