Immune response of patients with recurrent aphthous stomatitis challenged with a symbiotic

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dc.contributor.author Mimura, Maria Angela Martins [UNIFESP]
dc.contributor.author Borra, Ricardo Carneiro
dc.contributor.author Hirata, Cleonice Hitomi Watashi [UNIFESP]
dc.contributor.author Penido, Norma de Oliveira [UNIFESP]
dc.date.accessioned 2018-04-27T11:25:56Z
dc.date.available 2018-04-27T11:25:56Z
dc.date.issued 2017-10-04
dc.identifier https://onlinelibrary.wiley.com/doi/abs/10.1111/jop.12621 pt
dc.identifier.citation Mimura Maria Angela Martins, Borra Ricardo Carneiro, Hirata Cleonice Hitomi Watashi, Penido Norma de Oliveira. Immune response of patients with recurrent aphthous stomatitis challenged with a symbiotic. J Oral Pathol Med. 2017;46:821–828. https://doi.org/10.1111/jop.12621 en
dc.identifier.issn 1600-0714
dc.identifier.issn 0904-2512
dc.identifier.uri http://repositorio.unifesp.br/11600/41779
dc.description.abstract Background: There are indications that Th1 polarization of immune response plays an important role in the pathogenesis of recurrent aphthous stomatitis (RAS), and that the use of probiotics can stimulate immune regulatory activity, influencing the course of the disease. The aim of this study was to characterize the initial immune profile of RAS patients and evaluate clinical and serological response following a challenge with symbiotic treatment containing fructooligosaccharide, Lactobacillus, and Bifidobacterium. Methods: The immune responses of the 45 patients with RAS, submitted to symbiotic or placebo for 120 days, in relation to 30 RAS-free controls, were evaluated over a period of 6 months. Peripheral blood was collected from all patients at 0 (T0), 120 (T4), and 180 days (T6) after the start of treatment and Th1 (IL12-p70,IFN-c), Th2 (IL-4), Treg (IL-10), Th17 (IL-17A), inflammatory (TNF-a, IL-6)-associated cytokines, and clinical parameters were quantified. Results: At T0, significant differences were found in the serological levels of the IFN-c, IL-4, and IL-6 cytokines of the RAS patients in comparison with the controls. It was observed that the cytokine profile of the RAS group was comprised of 2 distinct clusters: a pure Th2 and a Mixed (Th1/Th2) subtype and that symbiotic treatment induced an improvement in pain and an increase in IFN-c levels, producing a reduction in Th2 response. Conclusions: In RAS, symbiotic treatment based on a fructooligosaccharide, Lactobacillus, and Bifidobacterium composition produced an alteration in the Th2 serological immune profile in the direction of Th1 and improved pain symptomatology. pt
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) pt
dc.language.iso eng
dc.publisher Wiley
dc.rights Acesso restrito pt
dc.subject Cytokines en
dc.subject Immunology en
dc.subject Recurrent aphthous stomatitis en
dc.subject Treatment en
dc.title Immune response of patients with recurrent aphthous stomatitis challenged with a symbiotic en
dc.type Artigo pt
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista de Medicina (UNIFESP/EPM), Dept Otorhinolaryngol Head & Neck Surg, São Paulo, Brazil
dc.description.affiliation Univiversidade Federal de São Carlos UFSCAR, Dept Genet & Evolucao, Sao Carlos, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista de Medicina (UNIFESP/EPM), Dept Otorhinolaryngol Head & Neck Surg, São Paulo, Brazil
dc.identifier.doi 10.1111/jop.12621 pt
dc.identifier.wos WOS:000412303500025



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