Effect of sildenafil (Viagra®) on the genital reflexes of paradoxical sleep-deprived male rats

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dc.contributor.author Andersen, Monica Levy [UNIFESP]
dc.contributor.author Bignotto, Magda [UNIFESP]
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.date.accessioned 2015-06-14T13:37:10Z
dc.date.available 2015-06-14T13:37:10Z
dc.date.issued 2007-11-01
dc.identifier http://dx.doi.org/10.1590/S0100-879X2006005000180
dc.identifier.citation Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 11, p. 1473-1480, 2007.
dc.identifier.issn 0100-879X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/3981
dc.description.abstract Since there is evidence that paradoxical sleep deprivation (PSD) elicits penile erection (PE) and ejaculation (EJ), and that the erectile response of rats is mediated by nitric oxide, the present study sought to extend the latter finding by assessing the effects of sildenafil on the genital reflexes of male Wistar rats subjected to PSD. We also determined the influence of sildenafil on hormone concentrations. In the first experiment, sildenafil at doses ranging from 0.08 to 0.32 mg/kg was administered intraperitoneally to rats that had been deprived of sleep for 4 days and to home cage controls (N = 8-10/group). The frequency of PE and EJ was measured for 60 min. PSD alone induced PE in 50% of the animals; however, a single injection of sildenafil did not significantly increase the percentage of rats displaying PE compared to PSD-saline or to home cage groups. PSD alone also induced spontaneous EJ, but this response was not potentiated by sildenafil in the dose range tested. Testosterone concentrations were significantly lower in PSD rats (137 ± 22 ng/dL) than in controls (365 ± 38 ng/dL), whereas progesterone (0.9 ± 0.1 vs 5.4 ± 1 ng/mL) and plasma dopamine (103.4 ± 30 vs 262.6 ± 77 pg/mL) increased. These changes did not occur after sildenafil treatment. The data show that although sildenafil did not alter the frequency of genital reflexes, it antagonized hormonal (testosterone and progesterone) and plasma dopamine changes induced by PSD. The stimulation of the genital reflexes by sildenafil did not result in potentiating effects in PSD rats. en
dc.format.extent 1473-1480
dc.language.iso eng
dc.publisher Associação Brasileira de Divulgação Científica
dc.relation.ispartof Brazilian Journal of Medical and Biological Research
dc.rights Acesso aberto
dc.subject Paradoxical sleep deprivation en
dc.subject Sildenafil en
dc.subject Genital reflexes en
dc.subject Dopamine en
dc.subject Testosterone en
dc.subject Progesterone en
dc.title Effect of sildenafil (Viagra®) on the genital reflexes of paradoxical sleep-deprived male rats en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Psicobiologia
dc.description.affiliationUnifesp UNIFESP, EPM, Depto. de Psicobiologia
dc.identifier.file S0100-879X2007001100008.pdf
dc.identifier.scielo S0100-879X2007001100008
dc.identifier.doi 10.1590/S0100-879X2006005000180
dc.description.source SciELO
dc.identifier.wos WOS:000250175400008



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