Behavioural changes observed in demyelination model shares similarities with white matter abnormalities in humans

Show simple item record

dc.contributor.author Serra-de-Oliveira, Nathalia [UNIFESP]
dc.contributor.author Boilesen, Sabine Nunes [UNIFESP]
dc.contributor.author Franca Carvalho, Carolina Prado de [UNIFESP]
dc.contributor.author LeSueur-Maluf, Luciana [UNIFESP]
dc.contributor.author Zollner, Ricardo de Lima
dc.contributor.author Spadari, Regina Celia [UNIFESP]
dc.contributor.author Medalha, Carla Cristina [UNIFESP]
dc.contributor.author Castro, Glaucia Monteiro de [UNIFESP]
dc.date.accessioned 2016-01-24T14:40:35Z
dc.date.available 2016-01-24T14:40:35Z
dc.date.issued 2015-07-01
dc.identifier http://dx.doi.org/10.1016/j.bbr.2015.03.038
dc.identifier.citation Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 287, p. 265-275, 2015.
dc.identifier.issn 0166-4328
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/39148
dc.description.abstract Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS). Further to the symptoms resulting from demyelination, new studies point to the involvement of neuroinflammation and white matter abnormalities in psychiatric disorders and neurodegenerative diseases. Cuprizone, a model of MS, produces consistent demyelination and elicits behavioural, morphological and inflammatory changes in animals that share some similarities with those observed in humans. in this study, we used the cuprizone model in Lewis rats to evaluate clinical signs triggered by the demyelination process which could be comparable with the symptoms seen in white matter abnormalities in human beings. To induce the demyelination process, 0.6% cuprizone was added to the Lewis rats' diet for 4 weeks. We proceeded with behavioural, morphological and immunological analyses. Animals fed with cuprizone exhibited behavioural changes: higher scores in the neurotoxicity test, reduced exploratory and locomotion behaviour, and also an increase of permanency in the closed arm of the elevated plus maze test, were observed. in these analyses, the animals showed motor coordination impairment and anxiety-like behaviour. Demyelination also triggered changes in discrimination of objects identified by an increase in the time spent close to a familiar object. These behavioural alterations were associated with a significant increase in the levels of TNF-alpha and corticosterone, consistent with the activation of microglia and astrocytes. Taken together, the results of this work show the cuprizone/Lewis rat model demyelination as an attractive paradigm for studying the correlation between white matter abnormalities and behaviour. (C) 2015 Elsevier B.V. All rights reserved. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent 265-275
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Behavioural Brain Research
dc.rights Acesso restrito
dc.subject Behaviour en
dc.subject Cognition en
dc.subject Cuprizone en
dc.subject Neuroinflammation en
dc.subject White matter en
dc.title Behavioural changes observed in demyelination model shares similarities with white matter abnormalities in humans en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade Estadual de Campinas (UNICAMP)
dc.description.affiliation Universidade Federal de São Paulo, UNIFESP, Programa Interdisciplinar Ciencias Saude, BR-11060001 Santos, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, UNIFESP, Dept Biociencias, BR-11015020 Santos, SP, Brazil
dc.description.affiliation Univ Estadual Campinas, UNICAMP, FCM, LIAE, BR-13083887 Campinas, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, UNIFESP, Programa Interdisciplinar Ciencias Saude, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, UNIFESP, Dept Biociencias, BR-11015020 Santos, SP, Brazil
dc.description.sponsorshipID FAPESP: 07/07828-3
dc.identifier.doi 10.1016/j.bbr.2015.03.038
dc.description.source Web of Science
dc.identifier.wos WOS:000355037700034



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account