A multinational study to compare prevalence of atopic dermatitis in the first year of life

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dc.contributor.author Draaisma, Eelco
dc.contributor.author Garcia-Marcos, Luis
dc.contributor.author Mallol, Javier
dc.contributor.author Sole, Dirceu [UNIFESP]
dc.contributor.author Perez-Fernandez, Virginia
dc.contributor.author Brand, Paul L. P.
dc.contributor.author EISL Study Grp
dc.date.accessioned 2016-01-24T14:40:34Z
dc.date.available 2016-01-24T14:40:34Z
dc.date.issued 2015-06-01
dc.identifier http://dx.doi.org/10.1111/pai.12388
dc.identifier.citation Pediatric Allergy and Immunology. Hoboken: Wiley-Blackwell, v. 26, n. 4, p. 359-366, 2015.
dc.identifier.issn 0905-6157
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/39138
dc.description.abstract BackgroundAtopic dermatitis (AD) is common in childhood, with peak prevalence in early childhood. However, international comparisons of prevalence have focused on older children. We analysed differences in prevalence rates of AD and the associations with putative risk and protective factors, among infants in two European and two Central American countries.MethodsIn 1-yr old infants participating in the International Study of Wheezing in Infants (EISL), prevalence of AD and putative risk and protective factors were assessed by a questionnaire applied to parents. for each risk/protective factor summary, odds ratios with 95% confidence intervals were calculated by means of random effects meta-analysis.ResultsData from 9803 infants were analysed. AD prevalence varied from 10.6% (Valencia, Spain) to 28.2% (San Pedro Sula, Honduras). Average AD prevalences were lower in Europe (14.2%) than in Central America (18.2%, p<0.01). Consistent with older children, presence of siblings decreased (OR 0.82 [0.72-0.94]), whereas family history of asthma (OR 1.32 [1.10-1.59]), rhinitis (OR 1.33 [1.14-1.54]) and atopic dermatitis (OR 2.40 [1.89-3.05]) increased the risk of infantile AD. However, gender, family size, breastfeeding and socio-economic status were not associated with AD prevalence.ConclusionsThis study shows almost threefold differences in the prevalence of AD in infancy between countries. Risk and protective factors involved in the expression of infantile AD differ from those in older children, possibly suggesting a different pathophysiology. There is a need for additional international epidemiological surveys on AD in young children, the peak prevalence age of this condition. en
dc.description.sponsorship Foundation to Combat Asthma (Stichting Astma Bestrijding) in the Netherlands
dc.description.sponsorship Spanish government
dc.format.extent 359-366
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Pediatric Allergy and Immunology
dc.rights Acesso restrito
dc.subject atopic dermatitis en
dc.subject infants en
dc.subject international en
dc.subject prevalence en
dc.subject protective factors en
dc.subject risk factors en
dc.title A multinational study to compare prevalence of atopic dermatitis in the first year of life en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Isala Hosp
dc.contributor.institution Univ Murcia
dc.contributor.institution Arrixaca Biohlth Res Inst Murcia
dc.contributor.institution Univ Santiago Chile USACH
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Med Ctr Groningen
dc.contributor.institution Univ Groningen
dc.description.affiliation Isala Hosp, Princess Amalia Childrens Ctr, NL-8000 GK Zwolle, Netherlands
dc.description.affiliation Univ Murcia, Virgen de la Arrixaca Univ Childrens Hosp, Pediat Resp Unit, Murcia, Spain
dc.description.affiliation Univ Murcia, Virgen de la Arrixaca Univ Childrens Hosp, Allergy Unit, Murcia, Spain
dc.description.affiliation Arrixaca Biohlth Res Inst Murcia, Murcia, Spain
dc.description.affiliation Univ Santiago Chile USACH, Hosp El Pino, Dept Pediat Resp Med, Santiago, Chile
dc.description.affiliation Fed Univ São Paulo UNIFESP, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, São Paulo, Brazil
dc.description.affiliation Univ Med Ctr Groningen, UMCG Postgrad Sch Med, Groningen, Netherlands
dc.description.affiliation Univ Groningen, Groningen, Netherlands
dc.description.affiliationUnifesp Fed Univ São Paulo UNIFESP, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, São Paulo, Brazil
dc.description.sponsorshipID Spanish government: PI050480
dc.description.sponsorshipID Spanish government: A/3069/05
dc.description.sponsorshipID Spanish government: A/5189/06
dc.description.sponsorshipID Spanish government: A/8579/07
dc.description.sponsorshipID Spanish government: A/8585/07
dc.identifier.doi 10.1111/pai.12388
dc.description.source Web of Science
dc.identifier.wos WOS:000355149800009



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