A multinational study to compare prevalence of atopic dermatitis in the first year of life

A multinational study to compare prevalence of atopic dermatitis in the first year of life

Author Draaisma, Eelco Google Scholar
Garcia-Marcos, Luis Google Scholar
Mallol, Javier Google Scholar
Sole, Dirceu Autor UNIFESP Google Scholar
Perez-Fernandez, Virginia Google Scholar
Brand, Paul L. P. Google Scholar
EISL Study Grp Google Scholar
Institution Isala Hosp
Univ Murcia
Arrixaca Biohlth Res Inst Murcia
Univ Santiago Chile USACH
Universidade Federal de São Paulo (UNIFESP)
Univ Med Ctr Groningen
Univ Groningen
Abstract BackgroundAtopic dermatitis (AD) is common in childhood, with peak prevalence in early childhood. However, international comparisons of prevalence have focused on older children. We analysed differences in prevalence rates of AD and the associations with putative risk and protective factors, among infants in two European and two Central American countries.MethodsIn 1-yr old infants participating in the International Study of Wheezing in Infants (EISL), prevalence of AD and putative risk and protective factors were assessed by a questionnaire applied to parents. for each risk/protective factor summary, odds ratios with 95% confidence intervals were calculated by means of random effects meta-analysis.ResultsData from 9803 infants were analysed. AD prevalence varied from 10.6% (Valencia, Spain) to 28.2% (San Pedro Sula, Honduras). Average AD prevalences were lower in Europe (14.2%) than in Central America (18.2%, p<0.01). Consistent with older children, presence of siblings decreased (OR 0.82 [0.72-0.94]), whereas family history of asthma (OR 1.32 [1.10-1.59]), rhinitis (OR 1.33 [1.14-1.54]) and atopic dermatitis (OR 2.40 [1.89-3.05]) increased the risk of infantile AD. However, gender, family size, breastfeeding and socio-economic status were not associated with AD prevalence.ConclusionsThis study shows almost threefold differences in the prevalence of AD in infancy between countries. Risk and protective factors involved in the expression of infantile AD differ from those in older children, possibly suggesting a different pathophysiology. There is a need for additional international epidemiological surveys on AD in young children, the peak prevalence age of this condition.
Keywords atopic dermatitis
protective factors
risk factors
Language English
Sponsor Foundation to Combat Asthma (Stichting Astma Bestrijding) in the Netherlands
Spanish government
Grant number Spanish government: PI050480
Spanish government: A/3069/05
Spanish government: A/5189/06
Spanish government: A/8579/07
Spanish government: A/8585/07
Date 2015-06-01
Published in Pediatric Allergy and Immunology. Hoboken: Wiley-Blackwell, v. 26, n. 4, p. 359-366, 2015.
ISSN 0905-6157 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 359-366
Origin http://dx.doi.org/10.1111/pai.12388
Access rights Closed access
Type Article
Web of Science ID WOS:000355149800009
URI http://repositorio.unifesp.br/handle/11600/39138

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