Immunophenotypic Profile and Increased Risk of Hospital Admission for Infection in Infants Born to Female Kidney Transplant Recipients

Immunophenotypic Profile and Increased Risk of Hospital Admission for Infection in Infants Born to Female Kidney Transplant Recipients

Author Ono, E. Autor UNIFESP Google Scholar
Santos, A. M. dos Autor UNIFESP Google Scholar
Viana, P. O. Autor UNIFESP Google Scholar
Dinelli, M. I. S. Autor UNIFESP Google Scholar
Sass, N. Autor UNIFESP Google Scholar
De Oliveira, L. Autor UNIFESP Google Scholar
Goulart, A. L. Autor UNIFESP Google Scholar
Moraes-Pinto, M. I. de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Children born to female kidney recipients are exposed to immunosuppressive drugs during gestation. Little is known about their immune system at birth or in the long term. Twenty-eight children born to female kidney recipients and 40 full-term children born to healthy mothers were evaluated. T, B, NK, NKT, T cells were assessed by flow cytometry and functional evaluation of T and dendritic cells after in vitro activation was performed at birth and at 8 months of age. At birth, infants born to female kidney recipients showed lower numbers of CD4+ T, NKT and intense reduction of B cells (median cells/mm(3), transplant: 153.7 X control: 512.4; p<0.001). There was also a reduced percentage of activated CD8+ T and of CD4+ regulatory T cells. Activated memory and exhausted memory B cells showed higher percentages among children exposed to immunosuppressors when compared to control group. At 8 months, most immune alterations were no longer observed, but four children still had low numbers of some lymphocyte subsets at this age. Children born to female kidney recipients had 4.351 (95% CI: 1.026-15.225; p=0.046) higher risk of hospital admission in the first months of lifesome, with severe clinical manifestationsthan those born to healthy women.
Keywords clinical research
practice
basic (laboratory) research
science
pediatrics
infectious disease
immunosuppression
immune modulation
B cell biology
immune deficiency
immunosuppressant
infection and infectious agents
pregnancy
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 01/11011-6
FAPESP: 08/06232-2
Date 2015-06-01
Published in American Journal of Transplantation. Hoboken: Wiley-Blackwell, v. 15, n. 6, p. 1654-1665, 2015.
ISSN 1600-6135 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 1654-1665
Origin http://dx.doi.org/10.1111/ajt.13143
Access rights Closed access
Type Article
Web of Science ID WOS:000354621200025
URI http://repositorio.unifesp.br/handle/11600/39136

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