Preserved cardiac autonomic dynamics during sleep in subjects with spinal cord injuries

Preserved cardiac autonomic dynamics during sleep in subjects with spinal cord injuries

Author Tobaldini, Eleonora Google Scholar
Proserpio, Paola Google Scholar
Sambusida, Katrina Google Scholar
Lanza, Andrea Google Scholar
Redaelli, Tiziana Google Scholar
Frigerio, Pamela Google Scholar
Fratticci, Lara Google Scholar
Rosa, Silvia Google Scholar
Casali, Karina R. Autor UNIFESP Google Scholar
Somers, Virend K. Google Scholar
Nobili, Lino Google Scholar
Montano, Nicola Google Scholar
Institution Ca Granda IRCCS Fdn
Univ Milan
Mayo Clin & Mayo Fdn
Osped Niguarda Ca Granda
L Sacco Hosp Vialba
Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Spinal cord injuries (SCI) are associated with altered cardiovascular autonomic control (CAC). Sleep is characterized by modifications of autonomic control across sleep stages; however, no data are available in SCI subjects on CAC during sleep. We aim to assess cardiac autonomic modulation during sleep in subjects with SCI.Patients and methods: 27 participants with a neurological and radiological diagnosis of cervical (Cerv, n = 12, ie, tetraplegic) and thoracic SCI (Thor, n = 15, ie, paraplegic) and healthy subjects (Controls) were enrolled. Overnight polysomnographic (PSG) recordings were obtained in all participants. Electrocardiography and respiration were extracted from PSG, divided into sleep stages [wakefulness (W), non-REM sleep (NREM) and REM] for assessment of CAC, using symbolic analysis (SA) and corrected conditional entropy (CCE). SA identified indices of sympathetic and parasympathetic modulation and CCE evaluated the degree of complexity of the heart period time series.Results: SA revealed a reduction of sympathetic and predominant parasympathetic control during NREM compared to W and REM in SCI patients, independent of the level of the lesion, similar to the Controls. in all three groups, complexity of autonomic regulation was higher in NREM compared to W and REM.Conclusions: in subjects with SCI, cardiac autonomic control changed across sleep stages, with a reduction of sympathetic and an increase of parasympathetic modulation during NREM compared to W and REM, and a parallel increase of complexity during NREM, which was similar to the Controls. Cardiac autonomic dynamics during sleep are maintained in SCI, independent of the level of the lesion. (C) 2014 Elsevier B.V. All rights reserved.
Keywords Sleep
Spinal cord injury
Autonomic nervous system
Symbolic analysis
Entropy measures
Language English
Sponsor NIH
National Center for Advancing Translational Sciences (NCATS)
Grant number NIH: HL65176
National Center for Advancing Translational Sciences (NCATS): UL1 TR000135
Date 2015-06-01
Published in Sleep Medicine. Amsterdam: Elsevier B.V., v. 16, n. 6, p. 779-784, 2015.
ISSN 1389-9457 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 779-784
Origin http://dx.doi.org/10.1016/j.sleep.2014.12.023
Access rights Closed access
Type Article
Web of Science ID WOS:000355136200016
URI http://repositorio.unifesp.br/handle/11600/39133

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account