Neuromyelitis optica spectrum disorders: beyond longitudinally extensive transverse myelitis

Neuromyelitis optica spectrum disorders: beyond longitudinally extensive transverse myelitis

Author Lemos, M. D. Autor UNIFESP Google Scholar
Carvalho, G. B. S. Autor UNIFESP Google Scholar
Carvalho, R. S. Autor UNIFESP Google Scholar
Bichuetti, D. B. Autor UNIFESP Google Scholar
Oliveira, E. M. L. de Autor UNIFESP Google Scholar
Abdala, Nitamar Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract AIM: To describe the neuroradiological features and their prevalence in patients with neuromyelitis optica (NMO).MATERIALS and METHODS: Two neuroradiologists independently reviewed 35 spinal cord and 37 brain MRI studies from patients with NMO. the examinations were analysed for the presence of lesion, topography, enhancement, and brain lesions suggestive of multiple sclerosis and/or NMO.RESULTS: Seventy percent of the spinal cord lesions involved over three or more vertebral segments. Seventy-eight percent of brain scans were abnormal, and the most prevalent findings were non-specific foci of T2 hyperintensities in the cerebral white matter (55%) and brainstem lesions (52%). One patient had lesions disseminated in space compatible with multiple sclerosis according to 2010 revised McDonald criteria. Brain lesions suggestive of NMO occurred at least once in 17 (59%) patients.CONCLUSION: Spinal cord lesions were often longitudinally extensive and brain lesions-were common, with the majority of patients having at least one distinctive NMO lesion. (C) 2015 the Royal College of Radiologists. Published by Elsevier B.V. All rights reserved.
Language English
Sponsor Bayer Health Care
Merck Serono
Date 2015-06-01
Published in Clinical Radiology. London: W B Saunders Co Ltd, v. 70, n. 6, p. 630-637, 2015.
ISSN 0009-9260 (Sherpa/Romeo, impact factor)
Publisher W B Saunders Co Ltd
Extent 630-637
Access rights Closed access
Type Article
Web of Science ID WOS:000355062200010

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