Effect of Raloxifene on Periapical Lesions in Ovariectomized Rats

Effect of Raloxifene on Periapical Lesions in Ovariectomized Rats

Author Gomes-Filho, Joao Eduardo Google Scholar
Wayama, Marcelo Tadahiro Google Scholar
Menegati Dornelles, Rita Cassia Google Scholar
Ervolino, Edilson Google Scholar
Coclete, Gilberto Aparecido Google Scholar
Tobias Duarte, Paulo Carvalho Google Scholar
Yamanri, Guilherme Hiroshi Google Scholar
Lodi, Carolina Simonetti Google Scholar
Dezan-Junior, Eloi Google Scholar
Angelo Cintra, Luciano Tavares Google Scholar
Institution Univ Estadual Paulista
Universidade Federal de São Paulo (UNIFESP)
Abstract Introduction: the aim of this study was to evaluate the effect of raloxifene (RLX) during progression of periapical lesions in ovariectomized (OVX) rats. Methods: Female Wistar rats were OVX or subjected to sham surgery and received vehicle or MX by gavage for 90 days. the treatment groups were as follows: sham surgery and treated with vehicle (SHAM-veh), OVX and treated with vehicle (OVX-veh), and OVX and treated with RLX (OVX-RLX). During treatment, the pulp of lower first molar was exposed to the oral. environment for induction of periapical lesion that was analyzed 7 or 30 days aftdr procedure. Blood samples were taken from jugular vein for measurement of estradiol, and the mandibles were removed and prepared for radiographic, histopathologic, histometric, and immunohistochemical analysis. Results: Estradiol plasma concentration showed hypoestrogenism in OVX rats. the histopathologic analysis of the OVX/RLX group was similar to that of the SHAM-veh group, whereas OVX-veh group showed larger penapical lesions with more intense inflammatory response and more cells positive for tartrate-resistant acid phosphatase. Radiographically, the groups were similar, but lesions on day 7 were smaller than lesions on day 30. Conclusions: the results suggest that hypoestrogenism potentiates the progression of periapical lesions, and such condition was reversed by treatment with RLX.
Keywords Bone metabolism
estrogen
ovariectomized
periapical lesion
raloxifene
Language English
Date 2015-05-01
Published in Journal of Endodontics. New York: Elsevier B.V., v. 41, n. 5, p. 671-675, 2015.
ISSN 0099-2399 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 671-675
Origin http://dx.doi.org/10.1016/j.joen.2014.11.027
Access rights Closed access
Type Article
Web of Science ID WOS:000354597200016
URI http://repositorio.unifesp.br/handle/11600/39049

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