Temporopolar blurring in temporal lobe epilepsy with hippocampal sclerosis and long-term prognosis after epilepsy surgery

Temporopolar blurring in temporal lobe epilepsy with hippocampal sclerosis and long-term prognosis after epilepsy surgery

Author Naves, Pedro Vicente Ferreira Autor UNIFESP Google Scholar
Caboclo, Luis Otavio S. F. Autor UNIFESP Google Scholar
Carrete, Henrique Autor UNIFESP Google Scholar
Kelmann, Bruno V. Autor UNIFESP Google Scholar
Gaça, Larissa Botelho Autor UNIFESP Google Scholar
Sandim, Gabriel B. Autor UNIFESP Google Scholar
Centeno, Ricardo S. Autor UNIFESP Google Scholar
Yacubian, Elza Márcia Targas Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Hosp Israelita Albert Einstein
Abstract Purpose: We conducted a retrospective study in order to investigate the clinical significance of temporopolar grey/white matter abnormalities (GWMA) in patients with temporal lobe epilepsy (TLE) and unilateral hippocampal sclerosis (HS) with a long post-surgical follow-up.Methods: the study comprised 122 consecutive patients with medically refractory TLE and unilateral HS who underwent epilepsy surgery and had a minimum postoperative follow-up of 5 years. Patients were divided into two groups, based on findings of pre-surgical MRI: group 1 with GWMA and 2 with normal signal and grey/white matter definition in temporal pole. Demographic and clinical data were reviewed and compared between groups.Results: GWMA were found in 52.5% of patients, always ipsilateral to HS. Compared with group 2, group 1 patients had earlier epilepsy onset (mean, 9.3 vs 14.4 years, P=0.001), a higher occurrence of first seizure <= 2 years of age (25.8% vs 10.5%, P=0.036; OR = 2.96 [95% CI =1.07-8.19]), and greater prevalence of left HS (76.6% vs 43.1%, P < 0.001; OR=4.31 [95% CI =1.98-9.38]). No differences were found in gender, presence or type of initial precipitating injury, history of secondary generalized seizures, duration of epilepsy, seizure frequency before surgery, neuropsychological evaluation and presence or lateralization of pre-surgical interictal epileptiform discharges. Postoperative follow-up varied from 5 to 11.5 years (mean 7.4) and was similar in both groups (P=0.155). the proportion of patients classified as seizure-free (Engel class I) at last follow-up in groups 1 and 2 were 73.4% and 69%, respectively (P=0.689). Similarly, the percentages of seizure-free patients with no antiepileptic drugs at last evaluation were not different between groups (P=0.817). in logistic regression analysis, left HS (P=0.001; OR =4.166 [95% CI =1.86-9.34]) and age at epilepsy onset <= 2 years (P=0.047; OR = 3.885 [95% CI =1.86-17.50]) were independently associated with risk of having GWMA.Conclusion: GWMA are frequent findings in patients with TLE and HS, and may help lateralize the epileptogenic zone. Our data support the hypothesis that GWMA are caused by seizure-related insults during the critical period of cerebral myelination. GWMA did not influence the postoperative seizure outcome of patients with TLE and HS, even after an extended duration of post-surgical follow-up. (C) 2015 Elsevier B.V. All rights reserved.
Keywords Temporal lobe epilepsy
Temporal pole blurring
Grey/white matter abnormalities
Epilepsy surgery
MRI
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2015-05-01
Published in Epilepsy Research. Amsterdam: Elsevier B.V., v. 112, p. 76-83, 2015.
ISSN 0920-1211 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 76-83
Origin http://dx.doi.org/10.1016/j.eplepsyres.2015.02.013
Access rights Closed access
Type Article
Web of Science ID WOS:000353845400010
URI http://repositorio.unifesp.br/handle/11600/39042

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