25-Hydroxyvitamin D level does not reflect intestinal calcium absorption: an assay using strontium as a surrogate marker

25-Hydroxyvitamin D level does not reflect intestinal calcium absorption: an assay using strontium as a surrogate marker

Author Rodrigues Camargo, Marilia Brasilio Autor UNIFESP Google Scholar
Vilaca, Tatiane Autor UNIFESP Google Scholar
Hayashi, Lilian Fukusima Autor UNIFESP Google Scholar
Ferreira Rocha, Olguita G. Google Scholar
Lazaretti-Castro, Marise Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Technol Ctr Minas Gerais CETEC
Abstract There is conflicting evidence as to the optimal serum 25-hydroxyvitamin D [25(OH)D] concentration for intestinal calcium absorption (Abs-Ca). Our purpose was to assess the relationship between vitamin D status and Abs-Ca in postmenopausal women. Fifty volunteers with low bone mass were grouped according to their serum 25(OH)D concentration as follows: mild deficient, < 50 nmol/L (DEF) and sufficient, a parts per thousand yen75 nmol/L (SUF). the subjects were submitted to an oral strontium overload test to assess their Abs-Ca. Fasting blood samples were obtained to perform the relevant hormonal and biochemical tests. After the subjects received the test solution, blood samples were drawn at 30, 60, 120, and 240 min to determine the strontium concentrations. Abs-Ca was indirectly expressed as the area under the serum strontium concentration curve (AUC). A repeated measures ANOVA was performed to determine the differences among the groups. Pearson's correlation and multiple linear regression analysis were used to study the associations between the variables. the mean 25(OH)D and 1,25-dihydroxyvitamin D [1,25(OH)(2)D] concentrations differed between the groups (SUF vs. DEF) as follows: 98.7 +/- A 18.2 vs. 38.4 +/- A 8.5 nmol/L (p < 0.001) and 36.2 +/- A 10.2 vs. 24.9 +/- A 4.6 pg/mL (p < 0.001), respectively. There was no statistically significant difference between the groups for parathyroid hormone and AUC. Only 1,25(OH)(2)D influenced the strontium absorption in the last 2 h of the test. in the studied population, no correlation between levels of 25(OH)D and Abs-Ca was found. Only 1,25(OH)(2)D influenced Abs-Ca as measured by a strontium absorption test.
Keywords Vitamin D
Calcium
Strontium
Intestinal absorption
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 08/55567-7
Date 2015-05-01
Published in Journal of Bone and Mineral Metabolism. Tokyo: Springer Japan Kk, v. 33, n. 3, p. 319-328, 2015.
ISSN 0914-8779 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 319-328
Origin http://dx.doi.org/10.1007/s00774-014-0592-8
Access rights Closed access
Type Article
Web of Science ID WOS:000354295200010
URI http://repositorio.unifesp.br/handle/11600/39027

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