Autoantibodies in systemic sclerosis: unanswered questions

Autoantibodies in systemic sclerosis: unanswered questions

Author Kayser, Cristiane Autor UNIFESP Google Scholar
Fritzler, Marvin J. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Calgary
Abstract Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular abnormalities, and cutaneous and visceral fibrosis. Serum autoantibodies directed to multiple intracellular antigens are present in more than 95% of patients and are considered a hallmark of SSc. They are helpful biomarkers for the early diagnosis of SSc and are associated with distinctive clinical manifestations. With the advent of more sensitive, multiplexed immunoassays, new and old questions about the relevance of autoantibodies in SSc are emerging. in this review, we discuss the clinical relevance of autoantibodies in SSc emphasizing the more recently published data. Moreover, we will summarize recent advances regarding the stability of SSc autoantibodies over the course of disease, whether they are mutually exclusive and their potential roles in the disease pathogenesis.
Keywords systemic sclerosis
scleroderma
autoantibodies
anti-nuclear antibodies
autoimmune diseases
Language English
Date 2015-04-15
Published in Frontiers in Immunology. Lausanne: Frontiers Research Foundation, v. 6, 6 p., 2015.
ISSN 1664-3224 (Sherpa/Romeo, impact factor)
Publisher Frontiers Research Foundation
Extent 6
Origin http://dx.doi.org/10.3389/fimmu.2015.00167
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000354934400001
URI http://repositorio.unifesp.br/handle/11600/39005

Show full item record




File

Name: WOS000354934400001.pdf
Size: 422.3Kb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account