Nosocomial bloodstream infections in a nationwide study: comparison between solid organ transplant patients and the general population

Nosocomial bloodstream infections in a nationwide study: comparison between solid organ transplant patients and the general population

Author Camargo, L. F. A. Autor UNIFESP Google Scholar
Marra, A. R. Autor UNIFESP Google Scholar
Pignatari, A. C. C. Autor UNIFESP Google Scholar
Sukiennik, T. Google Scholar
Behar, P. P. P. Google Scholar
Medeiros, E. A. S. Autor UNIFESP Google Scholar
Ribeiro, J. Google Scholar
Girao, E. Google Scholar
Correa, L. Google Scholar
Guerra, C. Google Scholar
Brites, C. Google Scholar
Pereira, C. A. P. Google Scholar
Carneiro, I. Google Scholar
Reis, M. Google Scholar
Souza, M. A. Google Scholar
Barata, C. U. Google Scholar
Edmond, M. B. Google Scholar
Brazilian SCOPE Study Grp Google Scholar
Institution Hosp Israelita Albert Einstein
Universidade Federal de São Paulo (UNIFESP)
Hosp 9 Julho
Santa Casa Porto Alegre
Hosp Conceicao
Hosp Base
Hosp Walter Cantidio
Hosp Rim & Hipertensao
Hosp Diadema
Hosp Espanhol
Inst Oncol Pediat IOP GRAAC
Hosp Coracao
Hosp UNIMED
Hosp Clin Goiania
Univ Fed Triangulo Mineiro
Virginia Commonwealth Univ
Abstract BackgroundThe incidence of bloodstream infection (BSI) varies according to the transplanted organ. Mortality can be as high as 24%, with a significant impact on graft survival. Transplantation is a risk factor for multidrug-resistant (MDR) organisms, but comparison with a non-transplanted population in a single large cohort has not been described.MethodsThis is a prospective nationwide study (16 centers) reporting data on 2364 monomicrobial nosocomial BSIs, comparing 83 episodes in solid organ transplant patients with 2447 BSIs occurring in the general hospital population.ResultsThe prevalence of groups of infecting organisms (gram-positive, gram-negative, and fungi) was similar between transplant patients and the general population and a similar crude mortality rate was observed (34.9% in transplant vs. 43.3% in non-transplant patients). Staphylococcus aureus was the single most frequently isolated organism in both groups, and Acinetobacter species was more frequently isolated in the general population. Regarding MDR organisms, Klebsiella species, and Enterobacter species resistant to cefepime, as well as Acinetobacter species resistant to meropenem, were significantly more frequent in transplant patients.ConclusionAntimicrobial resistance is higher, particularly among gram-negative bacteria in the transplant population, although the overall mortality rate between transplant and non-transplant patients with nosocomial BSI is similar.
Keywords bloodstream infection
hospital
transplantation
epidemiology
surveillance
Language English
Sponsor Pfizer Laboratories
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2015-04-01
Published in Transplant Infectious Disease. Hoboken: Wiley-Blackwell, v. 17, n. 2, p. 308-313, 2015.
ISSN 1398-2273 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 308-313
Origin http://dx.doi.org/10.1111/tid.12356
Access rights Closed access
Type Article
Web of Science ID WOS:000352219400019
URI http://repositorio.unifesp.br/handle/11600/38979

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