Beneficial Effects of a Multifaceted 1-Year Lifestyle Intervention on Metabolic Abnormalities in Obese Adolescents With and Without Sleep-Disordered Breathing

Beneficial Effects of a Multifaceted 1-Year Lifestyle Intervention on Metabolic Abnormalities in Obese Adolescents With and Without Sleep-Disordered Breathing

Author Corgosinho, Flavia Campos Autor UNIFESP Google Scholar
Ackel-D'Elia, Carolina Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Damaso, Ana Raimunda Autor UNIFESP Google Scholar
Piano, Aline de Autor UNIFESP Google Scholar
Sanches, Priscila de Lima Autor UNIFESP Google Scholar
Silveira Campos, Raquel Munhoz da Autor UNIFESP Google Scholar
Silva, Patricia Leao Autor UNIFESP Google Scholar
Carnier, June Autor UNIFESP Google Scholar
Tock, Lian Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Moreira, Gustavo Antonio Autor UNIFESP Google Scholar
Pradella-Hallinan, Marcia Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Mello, Marco Tulio de Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Weight Sci
Universidade Federal de Minas Gerais (UFMG)
Abstract Obesity is considered a chronic subinflammatory disease and is a risk factor for many diseases such as sleep-disordered breathing (SDB). Although the interaction between obesity and sleep has been explored, not much is known about SDB in the adolescent population. Thus, the aims of this study were, first, to verify the effect of 1 year of interdisciplinary therapy on inflammatory markers in SDB and without SDB and, second, to investigate the influence of SDB on the result of the therapy by comparing these groups. A total of 36 obese adolescents were enrolled; however, only 24 completed the therapy (SDB group, n=12; non-SDB obese group, n=12). Sleep, anthropometric, metabolic, and inflammatory profiles were evaluated at baseline and after the treatment. in both groups, the therapy was able to improve all anthropometric variables. Metabolic parameters such as insulin, homeostasis model assessment (HOMA), and quantitative insulin sensitivity check index (QUICKI) were significantly improved only in non-SDB group. in both groups, the inflammatory state was significantly improved by the reduction in the leptin/adiponectin ratio. After the intervention, both groups no longer presented the hyperleptinemic state, favoring not only the inflammatory state, but also neuroendocrine regulation. Regarding the sleep parameter, the SDB group improved significantly in all respiratory events, and after therapy only four patients remained with SDB. Furthermore, there was an increase in sleep time. the lifestyle intervention was able to improve anthropometric, metabolic, and inflammatory parameters in both groups; however, the presence of SDB impaired better results. the data supported that the inclusion of SDB in the metabolic syndrome because of the link shown between them.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
AFIP
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
CENESP
UNIFESP-EPM
CENSA
CEPE
Grant number FAPESP: 2008/53069-0
FAPESP: 2006/00684-3
FAPESP: 2011/50356-0
FAPESP: 2011/50414-0
FAPESP: 2013/04136-4
FAPESP: 9814303-3
CAPES: AUX-PE-PNPD 2566/2011
Date 2015-04-01
Published in Metabolic Syndrome and Related Disorders. New Rochelle: Mary Ann Liebert, Inc, v. 13, n. 3, p. 110-118, 2015.
ISSN 1540-4196 (Sherpa/Romeo, impact factor)
Publisher Mary Ann Liebert, Inc
Extent 110-118
Origin http://dx.doi.org/10.1089/met.2014.0110
Access rights Closed access
Type Article
Web of Science ID WOS:000351274800003
URI http://repositorio.unifesp.br/handle/11600/38964

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