Effects of ayahuasca on the development of ethanol-induced behavioral sensitization and on a post-sensitization treatment in mice

Effects of ayahuasca on the development of ethanol-induced behavioral sensitization and on a post-sensitization treatment in mice

Author Oliveira-Lima, A. J. Google Scholar
Santos, R. Autor UNIFESP Google Scholar
Hollais, A. W. Autor UNIFESP Google Scholar
Gerardi-Junior, C. A. Google Scholar
Baldaia, M. A. Autor UNIFESP Google Scholar
Wuo-Silva, R. Autor UNIFESP Google Scholar
Yokoyama, T. S. Autor UNIFESP Google Scholar
Costa, J. L. Google Scholar
Malpezzi-Marinho, E. L. A. Google Scholar
Ribeiro-Barbosa, P. C. Google Scholar
Berro, L. F. Autor UNIFESP Google Scholar
Frussa-Filho, R. Autor UNIFESP Google Scholar
Marinho, E. A. V. Google Scholar
Institution Univ Estadual Santa Cruz
Universidade Federal de São Paulo (UNIFESP)
Univ Braz Cubes
Criminalist Inst São Paulo
Abstract Background: Hallucinogenic drugs were used to treat alcoholic patients in the past, and recent developments in the study of hallucinogens led to a renewal of interest regarding the application of these drugs in the treatment of addiction. in this scenario, accumulating evidence suggests that the hallucinogenic brew ayahuasca (Aya) may have therapeutic effects on substance abuse problems.Methods: We investigated the effects of Aya on spontaneous locomotor activity and ethanol(Eth)-induced hyperlocomotion and subsequent locomotor sensitization by a two-injection protocol. Additionally, we tested the effect of Aya on an 8-day counter-sensitization protocol to modify sensitized responses induced by a repeated treatment with Eth (1.8 g/kg) for 8 alternate days.Results: Aya showed high sensitivity in preventing the development of Eth-induced behavioral sensitization, attenuating it at all doses (30, 100, 200, 300 or 500 mg/kg) without modifying spontaneous locomotor activity. At the highest doses (300 and 500 mg/kg), Aya also showed selectivity to both acute and sensitized Eth responses. Finally, a counter-sensitization strategy with 100 or 300 mg/kg of Aya for 8 consecutive days after the establishment of Eth-induced behavioral sensitization was effective in blocking its subsequent expression on an Eth challenge.Conclusions: We demonstrated that Aya not only inhibits early behaviors associated with the initiation and development of Eth addiction, but also showed effectiveness in reversing long-term drug effects expression, inhibiting the reinstatement of Eth-induced behavioral sensitization when administered in the Eth-associated environment. (C) 2015 Elsevier Inc. All rights reserved.
Keywords Ethanol
Ayahuasca
Spontaneous locomotion
Behavioral sensitization
Counter-sensitization
Mice
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundo de Auxilio aos Docentes e Alunos (FADA/UNIFESP)
Associacao Fundo de Incentivo Pesquisa (AFIP)
Date 2015-04-01
Published in Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 142, p. 28-36, 2015.
ISSN 0031-9384 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 28-36
Origin http://dx.doi.org/10.1016/j.physbeh.2015.01.032
Access rights Closed access
Type Article
Web of Science ID WOS:000352044000005
URI http://repositorio.unifesp.br/handle/11600/38956

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