Cut-off values of waist circumference to predict metabolic syndrome in obese adolescents

Cut-off values of waist circumference to predict metabolic syndrome in obese adolescents

Alternative title Los valores de corte de circunferencia de cintura para predecir el síndrome metabólico en adolescentes obesos
Author Masquio, Deborah Cristina Landi Autor UNIFESP Google Scholar
Ganen, Aline de Piano Autor UNIFESP Google Scholar
Campos, Raquel Munhoz da Silveira Autor UNIFESP Google Scholar
Sanches, Priscila de Lima Autor UNIFESP Google Scholar
Corgosinho, Flavia Campos Autor UNIFESP Google Scholar
Caranti, Danielle Autor UNIFESP Google Scholar
Tock, Lian Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Damaso, Ana Raimunda Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Weight Sci
Abstract Introduction: Metabolic syndrome (MetS) is a constellation of metabolic alterations related to abdominal obesity, inflammation and insulin resistance, which increase cardiovascular disease and mortality. the aims of the present study were to identify the prevalence of comorbidities and altered parameters in obese adolescents with and without MetS, and determine cut-off points of waist circumference to predict MetS.Methods: 195 obese adolescents were recruited and divided according to MetS diagnosis based on IDF criteria. Blood analyses of glucose, lipids, liver enzymes, adiponectin and leptin were measured. Insulin resistance was assessed by HOMA-IR, QUICK' and HOMA-AD. Visceral, subcutaneous and hepatic fat were ultrasonography obtained. Body composition was estimated by BOD POD system.Results: We observed a prevalence of 25% of MetS (n=50). the MetS group presented significantly higher body mass, BlVH, body fat (kg), free-fat mass (kg), waist circumference, visceral fat, glucose, insulin, insulin resistance, total-cholesterol, LDL-c, VLDL-c, triglycerides, liver enzymes, blood pressure and non-alcoholic fatty liver disease (NAFLD). Significant lower QUICKI and adiponectin were noted in MetS group. MetS girls presented significantly higher leptin/adiponectin ratio compared to Non-MetS girls. Cut-off points of 111.5 cm for boys and 104.6 cm for girls of waist circumference were suggested to predict metabolic syndrome. Moreover, waist circumference was positively correlated with visceral fat and the number of metabolic syndrome parameters.Conclusion: MetS group presented significantly higher metabolic alterations and inflammation compared to Non-MetS group. Waist circumference is considered an anthropometric measure predictor of metabolic syndrome in obese adolescents, being useful in clinical practice.
Keywords Metabolic syndrome
Cut off point
Waist circumference
Non-alcoholic fatty liver disease and inflammation
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
UNIFESP
AFIP
CEPE
CEMSA
Grant number CNPq: 141533/2012-9
CAPES: AUX-PE-PNPD 2566/2011
FAPESP: 2011/50356-0
FAPESP: 2011/50414-0
FAPESP: 2013/ 041364
Date 2015-04-01
Published in Nutricion Hospitalaria. Madrid: Aula Medica Ediciones, v. 31, n. 4, p. 1540-1550, 2015.
ISSN 0212-1611 (Sherpa/Romeo, impact factor)
Publisher Aula Medica Ediciones
Extent 1540-1550
Origin http://dx.doi.org/10.3305/nh.2015.31.4.8442
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000352928200012
URI http://repositorio.unifesp.br/handle/11600/38922

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