Neuropsychological and Behavioral Disturbance Correlates of Unawareness of Memory Impairment in Dementia: A Population-Based Study

Neuropsychological and Behavioral Disturbance Correlates of Unawareness of Memory Impairment in Dementia: A Population-Based Study

Author Mograbi, Daniel C. Google Scholar
Ferri, Cleusa P. Autor UNIFESP Google Scholar
Stewart, Robert Google Scholar
Sosa, Ana L. Google Scholar
Brown, Richard G. Google Scholar
Laks, Jerson Google Scholar
Morris, Robin G. Google Scholar
Institution KCL
Universidade Federal de São Paulo (UNIFESP)
Hosp Alemao Oswaldo Cruz
Universidade Federal do Rio de Janeiro (UFRJ)
Abstract Introduction: This study investigated in a community sample associations of 2 different measures of unawareness of memory impairment in dementia with cognitive variables and behavioral and psychological symptoms of dementia.Method: Designcross-sectional, population-based survey. Settingscommunity samples (n = 15 022) from 3 world regions (Latin America, China, and India). Participants829 people with dementia identified from standardized interviews and diagnostic algorithms. Measurementsunawareness of memory deficits was measured in 2 ways: comparison of participant subjective report with either objective performance on memory tests or informant report (IR). Associations were investigated using prevalence ratios and Poisson regressions. Differences in frequency of unawareness were explored with McNemar tests for each region and agreement between variables calculated with Cohen .Results: the unawareness variable based on comparison with performance was associated with cognitive variables, such as fluency (in China) and visuospatial impairments (Latin America and India), and behavioral symptoms, such as mania (Latin America) and hallucinations (China). the unawareness variable based on IR was associated only with behavioral symptoms, such as anxiety (in China and India) and hallucinations and mania (Latin America). Frequency of unawareness was significantly higher in the unawareness variable based on performance in India. Agreement between the 2 unawareness variables was moderate in Latin America and China but only slight in India.Conclusion: Different ways of measuring unawareness are differentially associated with influencing factors. Informant-based unawareness measures may be more subjective and less sensitive than variables taking into account actual performance on cognitive tests.
Keywords dementia
anosognosia
insight
awareness
10
66
community-based study
Language English
Sponsor Wellcome Trust
World Health Organisation
US Alzheimer's Association
FONDACIT
Rockefeller Foundation
GlaxoSmithKline
Novartis
Lundbeck
Pfizer
Eisai
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Department of Health via the National Institute for Health Research (NIHR) Specialist Biomedical Research Centre for Mental Health
Institute of Psychiatry at King's College London
Grant number Wellcome Trust: GR066133
Wellcome Trust: GR08002
US Alzheimer's Association: IIRG-04-1286
CAPES: 4276060
Date 2015-03-01
Published in Journal of Geriatric Psychiatry and Neurology. Thousand Oaks: Sage Publications Inc, v. 28, n. 1, p. 3-11, 2015.
ISSN 0891-9887 (Sherpa/Romeo, impact factor)
Publisher Sage Publications Inc
Extent 3-11
Origin http://dx.doi.org/10.1177/0891988714541868
Access rights Closed access
Type Article
Web of Science ID WOS:000349525800001
URI http://repositorio.unifesp.br/handle/11600/38862

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