Post-transplant soluble CD30 levels are associated with early subclinical rejection in kidney transplantation

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dc.contributor.author Grenzi, Patricia C. [UNIFESP]
dc.contributor.author Campos, Erika F. [UNIFESP]
dc.contributor.author Silva, Helio T.
dc.contributor.author Felipe, Claudia R.
dc.contributor.author Franco, Marcelo F. [UNIFESP]
dc.contributor.author Soares, Maria F.
dc.contributor.author Medina-Pestana, Jose O. [UNIFESP]
dc.contributor.author Gerbase-DeLima, Maria [UNIFESP]
dc.date.accessioned 2016-01-24T14:40:11Z
dc.date.available 2016-01-24T14:40:11Z
dc.date.issued 2015-03-01
dc.identifier http://dx.doi.org/10.1016/j.trim.2015.02.004
dc.identifier.citation Transplant Immunology. Amsterdam: Elsevier B.V., v. 32, n. 2, p. 61-65, 2015.
dc.identifier.issn 0966-3274
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/38843
dc.description.abstract Several studies have shown association of high pre- or post-transplant levels of soluble CD30 (sCD30) with acute rejection and poor late kidney transplant outcome. Our goal was to investigate whether sCD30 levels at month-3 post-transplant are associated with subclinical rejection, presence of CD30(+) cells within the graft, and expression of immune response genes in peripheral blood mononuclear cells. the study comprised 118 adult first kidney graft recipients, transplanted at a single center, receiving tacrolimus in low concentration. All were submitted to a protocol biopsy at month-3. Subclinical rejection was identified in 10 biopsies and sCD30 levels >= 61.88 ng/mL (P = 0.004), younger recipient age (P = 0.030) and non-Caucasian ethnicity (P = 0.011) were independently associated with this outcome. Rare CD30(+) cells were present in only two biopsies. There was a correlation between sCD30 levels and CD30 gene expression in peripheral blood mononuclear cells (r = 0.385, P = 0.043). These results show that high sCD30 levels are independent predictors of graft dysfunction and may contribute to patient selection protocols by indicating those who could benefit from a more thorough evaluation. (C) 2015 Elsevier B.V. All rights reserved. en
dc.description.sponsorship Associacao Fundo de Incentivo A Pesquisa (AFIP)
dc.format.extent 61-65
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Transplant Immunology
dc.rights Acesso restrito
dc.subject sCD30 en
dc.subject Subclinical rejection en
dc.subject Kidney transplantation en
dc.subject Post-transplant monitoring en
dc.subject Protocol biopsy en
dc.title Post-transplant soluble CD30 levels are associated with early subclinical rejection in kidney transplantation en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution AFIP
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Hosp Rim & Hipertensao
dc.contributor.institution Univ Fed Parana
dc.description.affiliation AFIP, Inst Imunogenet, BR-04040031 São Paulo, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, BR-04021001 São Paulo, SP, Brazil
dc.description.affiliation Hosp Rim & Hipertensao, BR-04038002 São Paulo, SP, Brazil
dc.description.affiliation Univ Fed Parana, BR-80060000 Curitiba, Parana, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, BR-04021001 São Paulo, SP, Brazil
dc.identifier.doi 10.1016/j.trim.2015.02.004
dc.description.source Web of Science
dc.identifier.wos WOS:000353072800001



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