Post-transplant soluble CD30 levels are associated with early subclinical rejection in kidney transplantation

Post-transplant soluble CD30 levels are associated with early subclinical rejection in kidney transplantation

Author Grenzi, Patricia C. Autor UNIFESP Google Scholar
Campos, Erika F. Autor UNIFESP Google Scholar
Silva, Helio T. Google Scholar
Felipe, Claudia R. Google Scholar
Franco, Marcelo F. Autor UNIFESP Google Scholar
Soares, Maria F. Google Scholar
Medina-Pestana, Jose O. Autor UNIFESP Google Scholar
Gerbase-DeLima, Maria Autor UNIFESP Google Scholar
Institution AFIP
Universidade Federal de São Paulo (UNIFESP)
Hosp Rim & Hipertensao
Univ Fed Parana
Abstract Several studies have shown association of high pre- or post-transplant levels of soluble CD30 (sCD30) with acute rejection and poor late kidney transplant outcome. Our goal was to investigate whether sCD30 levels at month-3 post-transplant are associated with subclinical rejection, presence of CD30(+) cells within the graft, and expression of immune response genes in peripheral blood mononuclear cells. the study comprised 118 adult first kidney graft recipients, transplanted at a single center, receiving tacrolimus in low concentration. All were submitted to a protocol biopsy at month-3. Subclinical rejection was identified in 10 biopsies and sCD30 levels >= 61.88 ng/mL (P = 0.004), younger recipient age (P = 0.030) and non-Caucasian ethnicity (P = 0.011) were independently associated with this outcome. Rare CD30(+) cells were present in only two biopsies. There was a correlation between sCD30 levels and CD30 gene expression in peripheral blood mononuclear cells (r = 0.385, P = 0.043). These results show that high sCD30 levels are independent predictors of graft dysfunction and may contribute to patient selection protocols by indicating those who could benefit from a more thorough evaluation. (C) 2015 Elsevier B.V. All rights reserved.
Keywords sCD30
Subclinical rejection
Kidney transplantation
Post-transplant monitoring
Protocol biopsy
Language English
Sponsor Associacao Fundo de Incentivo A Pesquisa (AFIP)
Date 2015-03-01
Published in Transplant Immunology. Amsterdam: Elsevier B.V., v. 32, n. 2, p. 61-65, 2015.
ISSN 0966-3274 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 61-65
Origin http://dx.doi.org/10.1016/j.trim.2015.02.004
Access rights Closed access
Type Article
Web of Science ID WOS:000353072800001
URI http://repositorio.unifesp.br/handle/11600/38843

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