Is there a role for leptin in the reduction of depression symptoms during weight loss therapy in obese adolescent girls and boys?

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dc.contributor.author Carvalho-Ferreira, Joana Pereira de [UNIFESP]
dc.contributor.author Masquio, Deborah Cristina Landi [UNIFESP]
dc.contributor.author Campos, Raquel Munhoz da Silveira [UNIFESP]
dc.contributor.author Dal Molin Netto, Bárbara [UNIFESP]
dc.contributor.author Corgosinho, Flavia Campos [UNIFESP]
dc.contributor.author Sanches, Priscila de Lima [UNIFESP]
dc.contributor.author Tock, Lian
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.contributor.author Mello, Marco Tulio de [UNIFESP]
dc.contributor.author Finlayson, Graham
dc.contributor.author Dâmaso, Ana Raimunda [UNIFESP]
dc.date.accessioned 2016-01-24T14:40:11Z
dc.date.available 2016-01-24T14:40:11Z
dc.date.issued 2015-03-01
dc.identifier https://dx.doi.org/10.1016/j.peptides.2014.11.010
dc.identifier.citation Peptides. New York: Elsevier B.V., v. 65, p. 20-28, 2015.
dc.identifier.issn 0196-9781
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/38840
dc.description.abstract Several studies have sought to clarify the association between adolescent obesity and psychological distress. Recently, a biological link between leptin resistance and depression has been proposed. the aim of the present study was to examine changes in leptin concentrations as a potential predictor of reduced depression symptoms in obese adolescents during long-term interdisciplinary weight loss therapy. Seventy-five obese adolescents (age: 16.28 +/- 2.37 years; BMI: 35.65 +/- 4.64 kg/m(2)) engaged in a long-term interdisciplinary therapy for weight loss. They were evaluated at baseline and after 1 year of treatment for body composition, serum analyses and depression symptomatology. After therapy, body mass BMI, fat mass (% and kg), waist circumference, visceral, subcutaneous and visceral/subcutaneous fat and depression symptoms decreased and lean mass (%) increased significantly. There was an improvement in inflammatory profiles with a significant reduction in leptin and increase in adiponectin. Regression analyses showed that decreased leptin predicted amelioration in depression symptoms independent of age, gender and changes in visceral fat, body mass, fat mass (%) and leptin/adiponectin ratio. These associations appear stronger in girls than boys. the attenuation of hyperleptinemia appears to play an important role in the association between weight loss and depression, particularly in obese girls. (C) 2015 Elsevier Inc. All rights reserved. en
dc.description.sponsorship AFIP
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship UNIFESP
dc.format.extent 20-28
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Peptides
dc.rights Acesso restrito
dc.subject Depression en
dc.subject Leptin en
dc.subject Leptin resistance en
dc.subject Obesity en
dc.subject Adolescents en
dc.subject Inflammation en
dc.title Is there a role for leptin in the reduction of depression symptoms during weight loss therapy in obese adolescent girls and boys? en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Weight Sci
dc.contributor.institution Univ Leeds
dc.description.affiliation Universidade Federal de São Paulo, Postgrad Program Interdisciplinary Hlth Sci, BR-11060001 Santos, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Postgrad Program Nutr, São Paulo, SP, Brazil
dc.description.affiliation Weight Sci, São Paulo, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Psychobiol, São Paulo, SP, Brazil
dc.description.affiliation Univ Leeds, Inst Psychol Sci, Leeds, W Yorkshire, England
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Postgrad Program Interdisciplinary Hlth Sci, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Postgrad Program Nutr, São Paulo, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psychobiol, São Paulo, SP, Brazil
dc.description.sponsorshipID FAPESP: 2011/50356-0
dc.description.sponsorshipID FAPESP: 2011/50414-0
dc.description.sponsorshipID FAPESP: 2013/041364
dc.description.sponsorshipID CAPES: BEX 14189/13-5
dc.identifier.doi 10.1016/j.peptides.2014.11.010
dc.description.source Web of Science
dc.identifier.wos WOS:000352808900004



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