Prevalence of allergic diseases and/or allergic sensitisation in children and adolescents with type 1 diabetes mellitus

Prevalence of allergic diseases and/or allergic sensitisation in children and adolescents with type 1 diabetes mellitus

Author Vitta-Nova, H. Autor UNIFESP Google Scholar
Spinola-Castro, A. M. Autor UNIFESP Google Scholar
Garcia, F. E. Autor UNIFESP Google Scholar
Sole, D. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: the prevalence of atopic diseases in children with type 1 diabetes mellitus (DM1) has been reported as lower. the aim of this study was to evaluate the prevalence of allergic diseases and allergic sensitisation in Brazilian children and adolescents with DM1.Patients and methods: 96 patients with DM1 (aged 4-18 years, 45 boys) followed for at least one year were evaluated for allergic disease through a detailed allergological anamnesis and skin prick tests (SPT) to inhalant allergens (Dermatophagoides pteronyssinus, D. farinae, Blomia tropicalis, Blattella germanica, Periplaneta americana, dog epithelium, cat epithelium, mix fungi), foods (cow's milk, egg-white, yolk, soy, wheat, corn), and positive (histamine 1 mg/ml) and negative (saline) controls. Wheals with a mean diameter of induration equal to or greater than 3 mm identified a positive SPT.Results: the prevalence values of rhinitis, asthma and atopic eczema (isolated or associated) were 68.0%, 59.1% and 44.4%, respectively. 20.6% of the patients had no allergic disease. 46.8% of the patients had been diagnosed with DM1 for at least four years and there was no relationship between the period of DM1 and the presence of allergic disease, nor of the gender. 48.0% patients were sensitised with predominance of D. pteronyssinus, B. topicalis and D. farinae. the frequency of positive SPT was significantly higher among patients with history of allergic disease (OR = 6.98, 95%CI: 2.60-18.74, p < 0.001).Conclusion: the prevalence of allergic diseases and sensitisation in patients with DM1 was higher than usually expected and deserves further investigation to identify possible causes for these findings and to evaluate their importance and influence on the metabolic control. (C) 2013 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.
Keywords Asthma
Allergic rhinitis
Atopic eczema
Type 1 diabetes mellitus
Language English
Date 2015-03-01
Published in Allergologia Et Immunopathologia. Barcelona: Elsevier Doyma Sl, v. 43, n. 2, p. 157-161, 2015.
ISSN 0301-0546 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 157-161
Access rights Closed access
Type Article
Web of Science ID WOS:000352746400007

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