The effect of menopause on objective sleep parameters: Data from an epidemiologic study in São Paulo, Brazil

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dc.contributor.author Hachul, Helena [UNIFESP]
dc.contributor.author Frange, Cristina [UNIFESP]
dc.contributor.author Bezerra, Andreia Gomes [UNIFESP]
dc.contributor.author Hirotsu, Camila [UNIFESP]
dc.contributor.author Pires, Gabriel Natan [UNIFESP]
dc.contributor.author Andersen, Monica Levy [UNIFESP]
dc.contributor.author Bittencourt, Lia [UNIFESP]
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.date.accessioned 2016-01-24T14:39:56Z
dc.date.available 2016-01-24T14:39:56Z
dc.date.issued 2015-02-01
dc.identifier http://dx.doi.org/10.1016/j.maturitas.2014.11.002
dc.identifier.citation Maturitas. Clare: Elsevier B.V., v. 80, n. 2, p. 170-178, 2015.
dc.identifier.issn 0378-5122
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/38651
dc.description.abstract Objective: Our objective was to investigate the influence of menopausal status on sleep patterns in a representative sample of women from São Paulo, Brazil.Study design: A population-based survey with a probabilistic three-stage cluster sample of the city of São Paulo was used to represent the local population according to gender, age (20-80 years) and socioeconomic status.Main outcome measures: the female participants answered a sleep questionnaire, underwent polysomnographic recording and allowed their hormone levels to be measured. They also completed a gynecological questionnaire for classification of the reproductive aging stages: premenopausal or reproductive, perimenopausal or menopausal transition, and postmenopausal, defined as being after 12 months of amenorrhea. Women were allocated into early (the first 5 years after menopause) and late (after the first 5 years) stages.Results: A total of 535 women were included in this study: 339 were premenopausal, 53 were early postmenopausal, 118 were late postmenopausal and 25 were using hormone therapy or isoflavone compounds. Our main findings were that women in postmenopause spent more time in N3 sleep, had a higher apnea-hypopnea index (AHI) and lower Sa02 compared with premenopausal women after an analysis adjusted for confounding factors. We found no significant differences between early and late postmenopausal women-in the adjusted analysis.Conclusion: Our results indicate menopause itself exerts a modest, but important influence on objective sleep patterns, independent of age, in particular on AHI and Sa02. (C) 2014 Elsevier Ireland Ltd. All rights reserved. en
dc.description.sponsorship AFIP
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 170-178
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Maturitas
dc.rights Acesso aberto
dc.subject Sleep en
dc.subject Polysomnography en
dc.subject Premenopausal en
dc.subject Postmenopausal en
dc.subject Population sample en
dc.subject Women en
dc.title The effect of menopause on objective sleep parameters: Data from an epidemiologic study in São Paulo, Brazil en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Casa Saude Santa Marcelina
dc.description.affiliation Universidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Ginecol, BR-04024002 São Paulo, Brazil
dc.description.affiliation Casa Saude Santa Marcelina, Dept Ginecol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Ginecol, BR-04024002 São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2014/15259-2
dc.description.sponsorshipID CNPq: 300674/2013-9
dc.identifier.doi 10.1016/j.maturitas.2014.11.002
dc.description.source Web of Science
dc.identifier.wos WOS:000349271200010



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