Differential effects of exercise on brain opioid receptor binding and activation in rats

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dc.contributor.author Arida, Ricardo Mario [UNIFESP]
dc.contributor.author Silva, Sergio Gomes da [UNIFESP]
dc.contributor.author Almeida, Alexandre Aparecido de [UNIFESP]
dc.contributor.author Cavlheiro, Esper Abrao [UNIFESP]
dc.contributor.author Zavala-Tecuapetla, Cecilia
dc.contributor.author Brand, Serge
dc.contributor.author Rocha, Luisa
dc.date.accessioned 2016-01-24T14:39:52Z
dc.date.available 2016-01-24T14:39:52Z
dc.date.issued 2015-01-01
dc.identifier http://dx.doi.org/10.1111/jnc.12976
dc.identifier.citation Journal of Neurochemistry. Hoboken: Wiley-Blackwell, v. 132, n. 2, p. 206-217, 2015.
dc.identifier.issn 0022-3042
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/38611
dc.description.abstract Physical exercise stimulates the release of endogenous opioid peptides supposed to be responsible for changes in mood, anxiety, and performance. Exercise alters sensitivity to these effects that modify the efficacy at the opioid receptor. Although there is evidence that relates exercise to neuropeptide expression in the brain, the effects of exercise on opioid receptor binding and signal transduction mechanisms downstream of these receptors have not been explored. Here, we characterized the binding and G protein activation of mu opioid receptor, kappa opioid receptor or delta opioid receptor in several brain regions following acute (7 days) and chronic (30 days) exercise. As regards short-(acute) or longterm effects (chronic) of exercise, overall, higher opioid receptor binding was observed in acute-exercise animals and the opposite was found in the chronic-exercise animals. the binding of [S-35]GTP gamma S under basal conditions (absence of agonists) was elevated in sensorimotor cortex and hippocampus, an effect more evident after chronic exercise. Divergence of findings was observed for mu opioid receptor, kappa opioid receptor, and delta opioid receptor receptor activation in our study. Our results support existing evidence of opioid receptor binding and G protein activation occurring differentially in brain regions in response to diverse exercise stimuli. en
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Instituto Nacional de Neurociencia Translacional (INNT)
dc.description.sponsorship National Council for Sciences and Technology of Mexico
dc.format.extent 206-217
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Journal of Neurochemistry
dc.rights Acesso restrito
dc.subject brain en
dc.subject DOR en
dc.subject exercise en
dc.subject KOR en
dc.subject MOR en
dc.subject opioid receptor en
dc.title Differential effects of exercise on brain opioid receptor binding and activation in rats en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Hosp Israelita Albert Einstein
dc.contributor.institution Ctr Res & Adv Studies
dc.contributor.institution Univ Basel
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Dept Fisiol, São Paulo, Brazil
dc.description.affiliation Hosp Israelita Albert Einstein, Inst Cerebro, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Disciplina Neurol Expt, São Paulo, Brazil
dc.description.affiliation Ctr Res & Adv Studies, Dept Pharmacobiol, Mexico City, DF, Mexico
dc.description.affiliation Univ Basel, Hosp Psychiat, Ctr Affect Stress & Sleep Disorders, Basel, Switzerland
dc.description.affiliation Univ Basel, Inst Exercise & Hlth Sci, Basel, Switzerland
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Dept Fisiol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Disciplina Neurol Expt, São Paulo, Brazil
dc.description.sponsorshipID National Council for Sciences and Technology of Mexico: 98386
dc.identifier.doi 10.1111/jnc.12976
dc.description.source Web of Science
dc.identifier.wos WOS:000348712000006



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