Differential effects of exercise on brain opioid receptor binding and activation in rats

Differential effects of exercise on brain opioid receptor binding and activation in rats

Author Arida, Ricardo Mario Autor UNIFESP Google Scholar
Silva, Sergio Gomes da Autor UNIFESP Google Scholar
Almeida, Alexandre Aparecido de Autor UNIFESP Google Scholar
Cavlheiro, Esper Abrao Autor UNIFESP Google Scholar
Zavala-Tecuapetla, Cecilia Google Scholar
Brand, Serge Google Scholar
Rocha, Luisa Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Hosp Israelita Albert Einstein
Ctr Res & Adv Studies
Univ Basel
Abstract Physical exercise stimulates the release of endogenous opioid peptides supposed to be responsible for changes in mood, anxiety, and performance. Exercise alters sensitivity to these effects that modify the efficacy at the opioid receptor. Although there is evidence that relates exercise to neuropeptide expression in the brain, the effects of exercise on opioid receptor binding and signal transduction mechanisms downstream of these receptors have not been explored. Here, we characterized the binding and G protein activation of mu opioid receptor, kappa opioid receptor or delta opioid receptor in several brain regions following acute (7 days) and chronic (30 days) exercise. As regards short-(acute) or longterm effects (chronic) of exercise, overall, higher opioid receptor binding was observed in acute-exercise animals and the opposite was found in the chronic-exercise animals. the binding of [S-35]GTP gamma S under basal conditions (absence of agonists) was elevated in sensorimotor cortex and hippocampus, an effect more evident after chronic exercise. Divergence of findings was observed for mu opioid receptor, kappa opioid receptor, and delta opioid receptor receptor activation in our study. Our results support existing evidence of opioid receptor binding and G protein activation occurring differentially in brain regions in response to diverse exercise stimuli.
Keywords brain
DOR
exercise
KOR
MOR
opioid receptor
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Instituto Nacional de Neurociencia Translacional (INNT)
National Council for Sciences and Technology of Mexico
Grant number National Council for Sciences and Technology of Mexico: 98386
Date 2015-01-01
Published in Journal of Neurochemistry. Hoboken: Wiley-Blackwell, v. 132, n. 2, p. 206-217, 2015.
ISSN 0022-3042 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 206-217
Origin http://dx.doi.org/10.1111/jnc.12976
Access rights Closed access
Type Article
Web of Science ID WOS:000348712000006
URI http://repositorio.unifesp.br/handle/11600/38611

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