Decreased centrality of subcortical regions during the transition to adolescence: A functional connectivity study

Decreased centrality of subcortical regions during the transition to adolescence: A functional connectivity study

Author Sato, Joao Ricardo Autor UNIFESP Google Scholar
Salum, Giovanni Abrahao Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Vieira, Gilson Google Scholar
Zugman, Andre Autor UNIFESP Google Scholar
Picon, Felipe Almeida Google Scholar
Pan, Pedro Mario Autor UNIFESP Google Scholar
Hoexter, Marcelo Queiroz Autor UNIFESP Google Scholar
Anes, Mauricio Google Scholar
Moura, Luciana Monteiro Autor UNIFESP Google Scholar
Gomes Del'Aquilla, Marco Antonio Autor UNIFESP Google Scholar
Crossley, Nicolas Google Scholar
Amaro Junior, Edson Google Scholar
Mcguire, Philip Google Scholar
Lacerda, Acioly L. T. Autor UNIFESP Google Scholar
Rohde, Luis Augusto Google Scholar
Miguel, Euripedes Constantino Google Scholar
Jackowski, Andrea Parolin Autor UNIFESP Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Institution Universidade Federal do ABC (UFABC)
Univ Fed Rio Grande do Sul
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Kings Coll London
CNPq
Abstract Investigations of brain maturation processes are a key step to understand the cognitive and emotional changes of adolescence. Although structural imaging findings have delineated clear brain developmental trajectories for typically developing individuals, less is known about the functional changes of this sensitive development period. Developmental changes, such as abstract thought, complex reasoning, and emotional and inhibitory control, have been associated with more prominent cortical control. the aim of this study is to assess brain networks connectivity changes in a large sample of 7- to 15-year-old subjects, testing the hypothesis that cortical regions will present an increasing relevance in commanding the global network. Functional magnetic resonance imaging (fMRI) data were collected in a sample of 447 typically developing children from a Brazilian community sample who were submitted to a resting state acquisition protocol. the fMRI data were used to build a functional weighted graph from which eigenvector centrality (EVC) was extracted. for each brain region (a node of the graph), the age-dependent effect on EVC was statistically tested and the developmental trajectories were estimated using polynomial functions.Our findings show that angular gyrus become more central during this maturation period, while the caudate; cerebellar tonsils, pyramis, thalamus; fusiform, parahippocampal and inferior semilunar lobe become less central. in conclusion, we report a novel finding of an increasing centrality of the angular gyrus during the transition to adolescence, with a decreasing centrality of many subcortical and cerebellar regions. (C) 2014 Elsevier Inc. All rights reserved.
Keywords Neurodevelopment
Neuroimaging
Networks
Children
Graph
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Wellcome Trust
Grant number FAPESP: 2013/10498-6
FAPESP: 2013/00506-1
CNPq: 573974/2008-0
FAPESP: 2008/57896-8
Date 2015-01-01
Published in Neuroimage. San Diego: Academic Press Inc Elsevier Science, v. 104, p. 44-51, 2015.
ISSN 1053-8119 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 44-51
Origin http://dx.doi.org/10.1016/j.neuroimage.2014.09.063
Access rights Closed access
Type Article
Web of Science ID WOS:000345393800004
URI http://repositorio.unifesp.br/handle/11600/38591

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