Follicular fluid lipid fingerprinting from women with PCOS and hyper response during IVF treatment

Show simple item record

dc.contributor.author Cordeiro, Fernanda Bertuccez [UNIFESP]
dc.contributor.author Cataldi, Thais Regiani [UNIFESP]
dc.contributor.author Teixeira da Costa, Livia do Vale [UNIFESP]
dc.contributor.author Lima, Camila Bruna de [UNIFESP]
dc.contributor.author Stevanato, Juliana [UNIFESP]
dc.contributor.author Zylbersztejn, Daniel Suslik [UNIFESP]
dc.contributor.author Ferreira, Christina Ramires
dc.contributor.author Eberlin, Marcos Nogueira
dc.contributor.author Cedenho, Agnaldo Pereira [UNIFESP]
dc.contributor.author Lo Turco, Edson Guimaraes [UNIFESP]
dc.date.accessioned 2016-01-24T14:39:48Z
dc.date.available 2016-01-24T14:39:48Z
dc.date.issued 2015-01-01
dc.identifier http://dx.doi.org/10.1007/s10815-014-0375-0
dc.identifier.citation Journal of Assisted Reproduction and Genetics. New York: Springer/plenum Publishers, v. 32, n. 1, p. 45-54, 2015.
dc.identifier.issn 1058-0468
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/38575
dc.description.abstract Polycystic ovary syndrome (PCOS) is an endocrine-metabolic disorder that leads to lower natural reproductive potential and presents a challenge for assisted reproductive medicine because patients may exhibit immature oocyte retrieval and a higher risk of ovarian hyper stimulation syndrome during in vitro fertilization (IVF) treatment. This study aimed to identify potential lipid biomarkers for women with PCOS and a hyper response to controlled ovarian stimulation.Follicular fluid samples were collected from patients who underwent IVF, including normal responder women who became pregnant (control group, n = 11), women with PCOS and a hyper response to gonadotropins (PCOS group, n = 7) and women with only hyper response to gonadotropins (HR group, n = 7). A lipidomic analysis was performed by electrospray ionization mass spectrometry, and candidate biomarkers were analyzed by tandem mass spectrometry experiment.The lipid profiles indicated particularities related to differences in phosphatidylcholine (PCOS and HR), phosphatidylserine, phosphatydilinositol and phosphatidylglycerol (control), sphingolipids (PCOS) and phosphatidylethanolamine (control and HR).These findings contribute to the understanding of the molecular mechanisms associated with lipid metabolism in the PCOS-related hyper response, and strongly suggest that these lipids may be useful as biomarkers, leading to the development of more individualized treatment for pregnancy outcome. en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 45-54
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Journal of Assisted Reproduction and Genetics
dc.rights Acesso restrito
dc.subject Polycystic ovary syndrome en
dc.subject Hyper response en
dc.subject Follicular fluid en
dc.subject Lipids en
dc.subject ESI-MS en
dc.title Follicular fluid lipid fingerprinting from women with PCOS and hyper response during IVF treatment en
dc.type Artigo
dc.rights.license http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade Estadual de Campinas (UNICAMP)
dc.description.affiliation Universidade Federal de São Paulo, Human Reprod Sect, Dept Surg, Div Urol, BR-04039060 São Paulo, Brazil
dc.description.affiliation Univ Estadual Campinas, Inst Chem, Campinas, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Human Reprod Sect, Dept Surg, Div Urol, BR-04039060 São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2012/06389-4
dc.identifier.doi 10.1007/s10815-014-0375-0
dc.description.source Web of Science
dc.identifier.wos WOS:000347949800006



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account