Low-level laser therapy in IL-1 beta, COX-2, and PGE2 modulation in partially injured Achilles tendon

Low-level laser therapy in IL-1 beta, COX-2, and PGE2 modulation in partially injured Achilles tendon

Author Jesus, Julio Fernandes de Autor UNIFESP Google Scholar
Spadacci-Morena, Diva Denelle Google Scholar
Anjos Rabelo, Nayra Deise dos Google Scholar
Pinfildi, Carlos Eduardo Autor UNIFESP Google Scholar
Fukuda, Thiago Yukio Google Scholar
Plapler, Helio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Inst Butantan
Univ Nove Julho UNINOVE
ISCMSP
Abstract This study evaluated IL-1 beta, COX-2, and PGE2 modulation in partially injured Achilles tendons treated with low-level laser therapy (LLLT). Sixty-five male Wistar rats were used. Sixty were submitted to a direct injury on Achilles tendon and then distributed into six groups: LASER 1 (a single LLLT application), LASER 3 (three LLLT applications), and LASER 7 (seven LLLT applications) and Sham 1, 3, and 7 (the same injury but LLLT applications were simulated). the five remaining animals were allocated at control group (no procedure performed). LLLT (780 nm) was applied with 70 mW of mean power and 17.5 J/cm(2) of fluency for 10 s, once a day. the tendons were surgically removed and assessed immunohistochemically for IL-1 beta, COX-2, and PGE2. in comparisons with control (IL-1 beta: 100.5 +/- 92.5 / COX-2: 180.1 +/- 97.1 / PGE2: 187.8 +/- 128.8) IL-1 beta exhibited (mean +/- SD) near-normal level (p > 0.05) at LASER 3 (142.0 +/- 162.4). COX-2 and PGE2 exhibited near-normal levels (p > 0.05) at LASER 3 (COX-2: 176.9 +/- 75.4 / PGE2: 297.2 +/- 259.6) and LASER 7 (COX-2: 259.2 +/- 190.4 / PGE2: 587.1 +/- 409.7). LLLT decreased Achilles tendon's inflammatory process.
Keywords Achilles tendon
Collagen
Inflammation
Low-level laser therapy
Tendinopathy
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2011/00979-1
Date 2015-01-01
Published in Lasers in Medical Science. London: Springer London Ltd, v. 30, n. 1, p. 153-158, 2015.
ISSN 0268-8921 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 153-158
Origin http://dx.doi.org/10.1007/s10103-014-1636-y
Access rights Closed access
Type Article
Web of Science ID WOS:000348297900021
URI http://repositorio.unifesp.br/handle/11600/38573

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