Safety and efficacy of various concentrations of topical lidocaine gel for intravitreal injection

Safety and efficacy of various concentrations of topical lidocaine gel for intravitreal injection

Author Shiroma, Helio Francisco Autor UNIFESP Google Scholar
Rodrigues, Eduardo Buchelle Autor UNIFESP Google Scholar
Farah, Michel E. Autor UNIFESP Google Scholar
Penha, Fernando M. Autor UNIFESP Google Scholar
Lorenzo, Jose Carlos Autor UNIFESP Google Scholar
Grumann, Astor Autor UNIFESP Google Scholar
Nunes, Renata Portella Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Introduction: Intravitreal injection (IVT) is one of the most common vitreoretinal procedures, a large majority are performed with local anesthesia. the purpose of this study was to investigate the safety to the cornea and anesthetic efficacy of five concentrations of lidocaine gel.Methods: A prospective clinical trial was conducted testing lidocaine gel in five preparations: 2, 3.5, 5, 8 and 12%. Patients with macular degeneration, diabetic edema or retina vein occlusion were scheduled for intravitreal treatment received topical anesthesia with lidocaine gel 5 and 10 min before the procedure. Patients answered the visual analog scale for pain during the procedure. Corneal and conjunctival was evaluated using the Oxford scale.Results: in total, 260 patients were randomized into five groups. the mean pain scores (+/- standard deviation) were 2.63 (+/- 1.68) in the 2% group, 2.08 (+/- 1.35) in the 3.5%; 2.00 (+/- 1.65) in the 5%, 1.93 (+/- 1.40) in the 8% and 1.83 (+/- 1.35) in the 12% group. Mean pain score among all groups was similar (p = 0.077). There was no significant difference between groups in regard to keratitis mean score (p = 0.897).Conclusions: Lidocaine gel at concentrations from 2 to 12% induced similar anesthetic effect for IVTs, without adverse effects on cornea and conjunctiva.
Keywords discomfort
intravitreal injection
ophthalmic lidocaine gel
pain
topical anesthesia
Language English
Date 2014-10-01
Published in Expert Opinion On Drug Safety. London: Informa Healthcare, v. 13, n. 10, p. 1299-1303, 2014.
ISSN 1474-0338 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 1299-1303
Origin http://dx.doi.org/10.1517/14740338.2014.947261
Access rights Closed access
Type Review
Web of Science ID WOS:000342281200003
URI http://repositorio.unifesp.br/handle/11600/38315

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