Long-term persistence of anti-beta 2 glycoprotein I in treated leprosy patients

Long-term persistence of anti-beta 2 glycoprotein I in treated leprosy patients

Author Ribeiro, S. L. E. Google Scholar
Pereira, H. L. A. Google Scholar
Silva, N. P. Autor UNIFESP Google Scholar
Sato, E. I. Autor UNIFESP Google Scholar
Passos, L. F. S. Google Scholar
Dos-Santos, M. C. Google Scholar
Institution Univ Fed Amazonas
Universidade Federal de São Paulo (UNIFESP)
Abstract 2 glycoprotein I (2GPI) is a phospholipid binding protein that plays an important role in endothelial stability, blood coagulation, clearance of apoptotic debris and other physiologic processes. Anti-2GPI antibodies occur in normal individuals and transiently during the course of infections, but are also associated with thrombotic events in autoimmune disease: the antiphospholipid syndrome (APS). A total of 31 out of 37 treated leprosy patients previously found to present high titers of IgM anti-2GPI and/or anticardiolipin antibodies (aCL) remained positive for IgM antiphospholipid antibodies (aPL), and exhibited high titers of anti-2GPI. the 37 patients were part of the 77 aPL-positive patients from a previous study that evaluated 158 leprosy patients. the median time elapsed between the first and second sample was 66 months. None of the 37 patients had any thrombotic event and 24 had a reactional state and were still requiring the use of prednisone, thalidomide or both. None of them fulfilled World Health Organization criteria for leprosy recurrence.
Keywords Anticardiolipin antibodies
antiphospholipid syndrome
anticoagulation
Language English
Date 2014-10-01
Published in Lupus. London: Sage Publications Ltd, v. 23, n. 12, p. 1249-1251, 2014.
ISSN 0961-2033 (Sherpa/Romeo, impact factor)
Publisher Sage Publications Ltd
Extent 1249-1251
Origin http://dx.doi.org/10.1177/0961203314529469
Access rights Closed access
Type Article
Web of Science ID WOS:000342741700008
URI http://repositorio.unifesp.br/handle/11600/38313

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