Can Ayahuasca and sleep loss change sexual performance in male rats?

Can Ayahuasca and sleep loss change sexual performance in male rats?

Author Alvarenga, T. A. Autor UNIFESP Google Scholar
Polesel, D. N. Autor UNIFESP Google Scholar
Matos, G. Autor UNIFESP Google Scholar
Garcia, V. A. Google Scholar
Costa, J. L. Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Andersen, M. L. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Pontificia Univ Catolica Rio Grande Sul PUCRS
Criminalist Inst São Paulo
Abstract The ingestion of the beverage Ayahuasca usually occurs in religious ceremonies that are performed during the night leading to sleep deprivation. the purpose of the present study was to characterize the acute effects of Ayahuasca upon the sexual response of sleep deprived male rats. One group of sexually experienced male Wistar rats were submitted to a paradoxical sleep deprivation (PSD) protocol for 96 h, while another group spent the same amount of time in the home cage (CTRL). After this period, either saline or Ayahuasca drink (250, 500 and 1000 mu g mL(-1)) was administered by gavage and sexual behavior and hormonal concentrations were measured. Ayahuasca alone significantly decreased sexual performance at all doses. However, in sleep deprived rats, the lower dose increased sexual performance while the intermediate dose produced a detrimental effect on sexual response compared to the CTRL rats at the same dose. Regarding the hormonal analyses, a lower testosterone concentration was observed in sleepdeprived saline rats in relation to the CTRL group. Progesterone was significantly lower only in PSD rats at the dose 500 mu g mL(-1) compared with CTRL-500 mu g mL(-1) group. Corticosterone was unchanged among the groups evaluated. Our results suggest that Ayahuasca intake markedly impaired sexual performance alone, but, when combined with sleep deprivation, had significant, but heterogeneous, effects on male sexual response. (C) 2014 Published by Elsevier B.V.
Keywords Ayahuasca
Sexual behavior
Sleep deprivation
Hormones
Testosterone
Male rats
Language English
Sponsor AFIP
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2014-10-01
Published in Behavioural Processes. Amsterdam: Elsevier B.V., v. 108, p. 110-116, 2014.
ISSN 0376-6357 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 110-116
Origin http://dx.doi.org/10.1016/j.beproc.2014.09.024
Access rights Closed access
Type Article
Web of Science ID WOS:000347599800017
URI http://repositorio.unifesp.br/handle/11600/38280

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