Safety assessment of cosmetic products, with emphasis on the ocular area: regulatory aspects and validation processes

Safety assessment of cosmetic products, with emphasis on the ocular area: regulatory aspects and validation processes

Author Cancian, Maythe de Lima Autor UNIFESP Google Scholar
Leonardi, Mauricio Saadi Google Scholar
Mosca, Mariane Martins Google Scholar
Guerra, Lucas Offenbecker Google Scholar
Hengeltraub, Simone Fanan Google Scholar
Leonardi, Gislaine Ricci Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Grp Invest
TRIDSKIN Labs Ltda
Abstract Before marketing a cosmetic product, a series of biological assays, such as ocular irritation tests, must be conducted in order to prove that the product is safe. However, a few scientific articles mention the discussion and evolution of cosmetic products testing performed in the eyes area. the aim of this study was to review the available literature on the evolution of tests carried out with cosmetics, in the ocular area, as well as to describe the methodologies that have been used and that are currently accepted. in Brazil, tests performed on animals are still allowed. However, the international laws strongly recommend the use of alternative methods for evaluating the risk of cosmetic ingredients and products. Regulatory requirements involving the registration of these products also request safety support of them in human beings. To perform ocular tests in human beings, it is necessary to involve an ophthalmologist for conducting clinical protocols. These protocols signed by the expert physician are sent to the National Health Surveillance Agency in order to endorse the product manufacturer concerning its safety. the safety support of a cosmetic product is very important, taking into account that the consumer has free access to these products of widespread use in today's society.
Keywords Eyes/cosmetics use
Cosmetics/safety assessment
Ocular irritation/tests
Ocular area/safety use of cosmetics
Language English
Date 2014-10-01
Published in Brazilian Journal of Pharmaceutical Sciences. São Paulo: Univ São Paulo, Conjunto Quimicas, v. 50, n. 4, p. 667-676, 2014.
ISSN 1984-8250 (Sherpa/Romeo, impact factor)
Publisher Univ São Paulo, Conjunto Quimicas
Extent 667-676
Origin http://dx.doi.org/10.1590/S1984-82502014000400002
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000350869000002
SciELO ID S1984-82502014000400002 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/38256

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