Serum crosslinked-N-terminal telopeptide of type I collagen (NTx) has prognostic implications for patients with initial prostate carcinbma (PCa): A pilot study

Serum crosslinked-N-terminal telopeptide of type I collagen (NTx) has prognostic implications for patients with initial prostate carcinbma (PCa): A pilot study

Author Jablonka, Fernando Google Scholar
Aguiar Alves, Beatriz da Costa Google Scholar
Bronzati de Oliveira, Claudia Giorgia Google Scholar
Wrodawski, Marcelo L. Google Scholar
Szwarc, Marcelo Google Scholar
Vitoria, Webster de Oliveira Google Scholar
Fonseca, Fernando Autor UNIFESP Google Scholar
Del Giglio, Auro Google Scholar
Institution ABC Med Sch
Universidade Federal de São Paulo (UNIFESP)
Abstract Background: NTx is a type I collagen metabolite previously shown to be increased in patients with bone metastasis. We evaluate NTx potential prognostic role in PCa at diagnosis, when most of the patients have no overt bone involvement.Methods: Men with histologic diagnosis of PCa were included at diagnosis. Serum NTx was measured serially every 3 months up to two years by ELISA. Fifty-five PCa patients with a median age of 67 y (51-83 y) were included. Most (86%) had stage I; 4% stage II; 2% stage III and 10% stage IV disease.Results: At entry, median NTx was 14.65 nMBCE and it did not correlate with age, Gleason score or PSA, but we observed a significant direct correlation with stage (p = 0.0094). With a median follow up of 23 months, serum NTx correlated significantly with biochemical recurrence (p = 0.012), as did Gleason score (p = 0.00056), stage (p = 0.012) and PSA (p < 0.0001). By multivariate analysis the only 2 independent variables significantly correlated with biochemical recurrence were PSA (p = 0.046) and NTx (p = 0.021).Conclusions: NTx serum concentrations may have a prognostic value in patients with PCa at diagnosis. These results emphasize the importance of bone metabolism biomarkers in patients with PCa even without evident overt bone involvement. (C) 2014 Elsevier B.V. All rights reserved.
Keywords Prostate cancer
Crosslinked-N-terminal telopeptide of type I collagen
Bone metabolism
Biomarkers
NTx
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 10/50490-6
Date 2014-09-25
Published in Clinica Chimica Acta. Amsterdam: Elsevier B.V., v. 436, p. 316-318, 2014.
ISSN 0009-8981 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 316-318
Origin http://dx.doi.org/10.1016/j.cca.2014.06.025
Access rights Closed access
Type Article
Web of Science ID WOS:000341463100051
URI http://repositorio.unifesp.br/handle/11600/38230

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