Assessment of antioxidants status and superoxide dismutase activity in HIV-infected children

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dc.contributor.author Pugliese, Camila [UNIFESP]
dc.contributor.author Patin, Rose Vega [UNIFESP]
dc.contributor.author Palchetti, Cecilia Zanin [UNIFESP]
dc.contributor.author Claudio, Cristiane Chiantelli [UNIFESP]
dc.contributor.author Gouvêa, Aida de Fátima Thomé Barbosa [UNIFESP]
dc.contributor.author Succi, Regina Célia de Menezes [UNIFESP]
dc.contributor.author Amancio, Olga Maria Silverio [UNIFESP]
dc.contributor.author Cozzolino, Silvia Maria Franciscato
dc.contributor.author Oliveira, Fernanda Luisa Ceragioli [UNIFESP]
dc.date.accessioned 2016-01-24T14:37:45Z
dc.date.available 2016-01-24T14:37:45Z
dc.date.issued 2014-09-01
dc.identifier http://dx.doi.org/10.1016/j.bjid.2014.02.003
dc.identifier.citation Brazilian Journal of Infectious Diseases. Salvador: Contexto, v. 18, n. 5, p. 481-486, 2014.
dc.identifier.issn 1413-8670
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/38115
dc.description.abstract Objective: This study aims to assess the nutritional status of selenium, copper and zinc; and also the erythrocyte superoxide dismutase activity of HIV-infected children compared to a control group.Methods: A cross-sectional study was carried out with prepubertal HIV-infected children (n = 51) and their healthy siblings (n = 32). All biochemical measurements including plasma selenium, serum copper levels, serum and erythrocyte zinc levels and erythrocyte superoxide dismutase activity were evaluated according to dietary, clinical and biochemical parameters.Results: Compared to the control group, the HIV-infected children had lower z-score values for height-for-age (p = 0.0006), higher prevalence of stunting (11.8%) (p = 0.047), lower selenium levels (p = 0.0006) and higher copper levels (p = 0.019). No difference was found concerning superoxide dismutase activity (p > 0.05). the HIV-infected group presented a higher proportion (45.1%) of children with zinc intakes below the estimated average requirement (p = 0.014); however, no association with zinc biochemical parameters was found.Conclusion: HIV-infected children have an inadequate selenium and copper nutritional status, which could influence the progression to AIDS. An adequate micronutrient status could improve the clinical conditions in these patients and minimize free radical production and cellular oxidative stress. (C) 2014 Elsevier Editora Ltda. All rights reserved. en
dc.format.extent 481-486
dc.language.iso eng
dc.publisher Contexto
dc.relation.ispartof Brazilian Journal of Infectious Diseases
dc.rights Acesso aberto
dc.subject Antioxidants en
dc.subject HIV and nutrition en
dc.subject Oxidative stress en
dc.subject Trace elements en
dc.title Assessment of antioxidants status and superoxide dismutase activity in HIV-infected children en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Universidade Federal de São Paulo UNIFESP EPM, Dept Pediat, Div Nutrol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo UNIFESP EPM, Dept Pediat, Div Pediat Infect Dis, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Fac Ciencias Farmaceut, Dept Food & Expt Nutr, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo UNIFESP EPM, Dept Pediat, Div Nutrol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo UNIFESP EPM, Dept Pediat, Div Pediat Infect Dis, São Paulo, Brazil
dc.identifier.file S1413-86702014000500481.pdf
dc.identifier.scielo S1413-86702014000500481
dc.identifier.doi 10.1016/j.bjid.2014.02.003
dc.description.source Web of Science
dc.identifier.wos WOS:000346072300003



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