BENEFICIAL INFLUENCE of PHYSICAL EXERCISE FOLLOWING STATUS EPILEPTICUS in the IMMATURE BRAIN of RATS

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dc.contributor.author Novaes Gomes, F. G. [UNIFESP]
dc.contributor.author Da Silva, S. Gomes [UNIFESP]
dc.contributor.author Cavalheiro, E. A. [UNIFESP]
dc.contributor.author Arida, R. M. [UNIFESP]
dc.date.accessioned 2016-01-24T14:37:44Z
dc.date.available 2016-01-24T14:37:44Z
dc.date.issued 2014-08-22
dc.identifier http://dx.doi.org/10.1016/j.neuroscience.2014.05.024
dc.identifier.citation Neuroscience. Oxford: Pergamon-Elsevier B.V., v. 274, p. 69-81, 2014.
dc.identifier.issn 0306-4522
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/38102
dc.description.abstract Studies in adult animals have demonstrated a beneficial effect of physical exercise on epileptic insults. Although the effects of physical exercise on the mature nervous system are well documented, its influence on the developing nervous system subjected to injuries in childhood has been little explored. the purpose of our study was to investigate whether a physical exercise program applied during brain development could influence the hippocampal plasticity of rats submitted to status epilepticus (SE) induced by pilocarpine model at two different ages of the postnatal period. Male Wistar rats aged 18 (P18) and 28 (P28) days were randomly divided into four groups: Control (CTRL), Exercise (EX), SE (SE) and SE Exercise (SE/EX) (n = 17 per group). After the aerobic exercise program, histological and behavioral (water maze) analyses were performed. Our results showed that only animals subjected to pilocarpine-induced SE at P28 presented spontaneous seizures during the observational period. A significant reduction in seizure frequency was observed in the SE/EX group compared to the SE group. in adulthood, animals submitted to early-life SE displayed impairment in long-term memory in the water maze task, while the exercise program reversed this deficit. Reduced mossy fiber sprouting in the dentate gyrus was noted in animals that presented spontaneous seizures (SE/EX vs SE). Exercise increased cell proliferation (Ki-67 staining) and anti-apoptotic response (bcl-2 staining) and reduced pro-apoptotic response (Bax staining) in animals of both ages of SE induction (P18/28). Exercise also modified the brain-derived neurotrophic factor (BDNF) levels in EX and SE/EX animals. Our findings indicate that in animals subjected to SE in the postnatal period a physical exercise program brings about beneficial effects on seizure frequency and hippocampal plasticity in later stages of life. (C) 2014 IBRO. Published by Elsevier B.V. All rights reserved. en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship INNT, Brazil
dc.format.extent 69-81
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Neuroscience
dc.rights Acesso restrito
dc.subject physical exercise en
dc.subject status epilepticus en
dc.subject immature brain en
dc.subject brain development en
dc.subject epilepsy en
dc.subject neuroplasticity en
dc.title BENEFICIAL INFLUENCE of PHYSICAL EXERCISE FOLLOWING STATUS EPILEPTICUS in the IMMATURE BRAIN of RATS en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Hosp Israelita Albert Einstein
dc.description.affiliation Universidade Federal de São Paulo UNIFESP, Dept Fisiol, BR-04023900 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Disciplina Neurol Expt, São Paulo, Brazil
dc.description.affiliation Hosp Israelita Albert Einstein, Inst Cerebro INCE, Inst Israelita Ensino & Pesquisa Albert Einstein, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo UNIFESP, Dept Fisiol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Disciplina Neurol Expt, São Paulo, Brazil
dc.identifier.doi 10.1016/j.neuroscience.2014.05.024
dc.description.source Web of Science
dc.identifier.wos WOS:000338712300008



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