The growth hormone receptor exon 3 polymorphism is not associated with height or metabolic traits in healthy young adults

The growth hormone receptor exon 3 polymorphism is not associated with height or metabolic traits in healthy young adults

Author Martins, Clarissa S. Google Scholar
Fernandes-Rosa, Fabio L. Google Scholar
Espineira, Aniette R. Google Scholar
Souza, Roberto Molina de Google Scholar
Castro, Margaret de Google Scholar
Barbieri, Marco A. Google Scholar
Bettiol, Heloisa Google Scholar
Jorge, Alexander L. Google Scholar
Antonini, Sonir R. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Context: the GHR polymorphisms contribution to the interindividual variability in prenatal and postnatal growth as well as to metabolic traits is controversial.Objective: the aim of this study is to analyze the association of the GHRfl/d3 polymorphism with prenatal and postnatal growth and metabolic outcomes in adult life and to compare the genotype distribution in different populations.Design: 385 community healthy subjects followed from birth to adult life (23-25 years old) were grouped according to birth size: small-SGA (n = 130, 62 males), appropriate-AGA (n = 162,75 males) and large for gestational age-LGA (n =- 93, 48 males). GHRfl/d3 genotype distribution and its potential association with anthropometric (at birth, childhood and adult life) and metabolic features (in adult life) were analyzed and compared with data obtained from a systematic review of GHRII/d3 association studies (31 articles).Results: the frequency of the GHR d3/d3 genotype was lower in the LGA (chi 2 p = 0.01); SGA and AGA subjects exhibited an increased chance of the d3/d3 genotype (OR = 3.58; 95%CI: 1.55; 8.24) and (OR = 239; 95%CI: 1.02; 5.62), respectively. Despite the different prevalence among different birth size groups, in adults, GHRfl/d3 genotype was not associated with height, plasma IGF1 levels or metabolic phenotype and cardiovascular risk. GHRfl/d3 genotype distributions in AGA, SGA and LGA groups were comparable with those found in subjects of European origin but not with those of Asian ancestry.Conclusions: the GHRd3 genotype was negatively associated with birth size but it was not associated with adult height or weight, plasma IGF1, metabolic phenotype or any marker of increased cardiovascular risk in young adults. (C) 2014 Elsevier B.V. All rights reserved.
Keywords Growth hormone receptor
Birth weight
Risk factors
Cardiovascular disease
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2005/60393-0
Date 2014-08-01
Published in Growth Hormone & Igf Research. Edinburgh: Churchill Livingstone, v. 24, n. 4, p. 123-129, 2014.
ISSN 1096-6374 (Sherpa/Romeo, impact factor)
Publisher Churchill Livingstone
Extent 123-129
Access rights Closed access
Type Article
Web of Science ID WOS:000339701900004

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