Ocular histoplasmosis-like syndrome: a report from a nonendemic area

Ocular histoplasmosis-like syndrome: a report from a nonendemic area

Alternative title Síndrome de histoplasmose ocular símile: relato de uma área não endêmica
Author Amaro, Miguel Hage Autor UNIFESP Google Scholar
Muccioli, Cristina Autor UNIFESP Google Scholar
Abreu, Mariza Toledo Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract PURPOSE: To report some cases of ocular histoplasmosis-like syndrome from a nonendemica area. DESIGN: Observational case series. METHODS: This is a prospective study of 16 eyes from 8 immunocompetent patients evaluated between January 2001 to September 2005. Six patients were female and 2 male aged between 20 to 44 years, average 28 years. All patients presented clinical features that resembled ocular histoplasmosis. All patients had a negative antibody test for histoplasmosis and negative medical and laboratory evaluation of toxoplasmosis, syphilis, and tuberculosis. All patients were submitted to a complete ocular examination including fluorescein angiography. One patient was submitted to indocyanine green angiography. RESULTS: Five patients presented the classical triad of clinical features that include peripapillary scarring, histo spots, choroidal neovascularization, one patient presentd enlargement of atrophic chorioretina scar, one patient presented multiple retinal pigment epithelial detachment, one, neovascularized retinal pigment epithelial detachment. Another patient presented only histo spots. CONCLUSION: These findings of ocular histoplasmosis-like syndrome in patients with negative antibody serum test from a nonendemica area suggest that other agents could cause these similar fundus findings of ocular histoplasmosis.

OBJETIVO: Descrevemos os achados clínicos oftalmológicos de 16 olhos de 8 pacientes imunocompetentes que apresentavam características fundoscópicas da síndrome de histoplasmose ocular. MÉTODOS: Os pacientes foram submetidos aos exames oculares de rotina e ainda à fluoresceinografia e à indocianinografia, além de exames laboratoriais para histoplasmome, toxoplasmose, sífilis, síndrome de insuficiência imunológica adquirida, tuberculose. RESULTADOS: Os exames fundoscópicos, fluoresceinográficos e indocianinográficos demonstraram múltiplas coroidites em saca-bocado, atrofia peripapilar e neovascularização de coróide. Os exames laboratoriais foram considerados normais. CONCLUSÃO: Uma outra etiologia que não a histoplasmose pode ser considerada para os achados encontrados. Uma micobactéria atípica ou o Mycobacterium avium que causam lesões semelhantes às descritas nos exames oculares podem ser consideradas.
Keywords Histoplasmosis
Eye infections, fungal
Fluorescein angiography
Fundus oculi
Choroidal neovascularization
Observational studies
Infecções oculares fungicas
Fundo de olho
Neovascularização coroidal
Estudos observacionais
Language English
Date 2007-08-01
Published in Arquivos Brasileiros de Oftalmologia. Conselho Brasileiro de Oftalmologia, v. 70, n. 4, p. 577-580, 2007.
ISSN 0004-2749 (Sherpa/Romeo)
Publisher Conselho Brasileiro de Oftalmologia
Extent 577-580
Origin http://dx.doi.org/10.1590/S0004-27492007000400003
Access rights Open access Open Access
Type Article
SciELO ID S0004-27492007000400003 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/3805

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