Emerging concepts about NAIP/NLIRC4 inflammasomes

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dc.contributor.author Lage, Silvia Lucena [UNIFESP]
dc.contributor.author Longo, Carla [UNIFESP]
dc.contributor.author Branco, Laura Migliari [UNIFESP]
dc.contributor.author Costa, Thais Boccia da [UNIFESP]
dc.contributor.author Buzzo, Carina de Lima [UNIFESP]
dc.contributor.author Bortoluci, Karina Ramalho [UNIFESP]
dc.date.accessioned 2016-01-24T14:37:35Z
dc.date.available 2016-01-24T14:37:35Z
dc.date.issued 2014-07-02
dc.identifier http://dx.doi.org/10.3389/fimmu.2014.00309
dc.identifier.citation Frontiers in Immunology. Lausanne: Frontiers Research Foundation, v. 5, 10 p., 2014.
dc.identifier.issn 1664-3224
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/37983
dc.description.abstract Neuronal apoptosis inhibitory protein (NAIP)/NOD-like receptor (NLR) containing a caspase activating and recruitment domain (CARD) 4 (NLRC4) inflammasome complexes are activated in response to proteins from virulent bacteria that reach the cell cytosol. Specific NAIP proteins bind to the agonists and then physically associate with NLRC4 to form an inflammasome complex able to recruit and activate pro-caspase-1. NAIP5 and NAIP6 sense flagellin, component of flagella from motile bacteria, whereas NAIP1 and NAIP2 detect needle and rod components from bacterial type III secretion systems, respectively. Active caspase-1 mediates the maturation and secretion of the pro-inflammatory cytokines, 11,113 and 11,18, and is responsible for the induction of pyroptosis, a pro-inflammatory form of cell death. in addition to these well-known effector mechanisms, novel roles have been described for NAIP/NLRC4 inflammasomes, such as phagosomal maturation, activation of inducible nitric oxide synthase, regulation of autophagy, secretion of inflammatory mediators, antibody production, activation of T cells, among others. These effector mechanisms mediated by NAIP/NLRC4 inflammasomes have been extensively studied in the context of resistance of infections and the potential of their agonists has been exploited in therapeutic strategies to non-infectious pathologies, such as tumor protection. Thus, this review will discuss current knowledge about the activation of NAIP/NLRC4 inflammasomes and their effector mechanisms. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship INCTV
dc.format.extent 10
dc.language.iso eng
dc.publisher Frontiers Research Foundation
dc.relation.ispartof Frontiers in Immunology
dc.rights Acesso aberto
dc.subject NAIP en
dc.subject NLRC4 en
dc.subject flagellin en
dc.subject caspase-1 en
dc.subject inflammasomes en
dc.subject lysosomes en
dc.subject cell death en
dc.title Emerging concepts about NAIP/NLIRC4 inflammasomes en
dc.type Resenha
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Ctr Terapia Celulare & Mol CTC Mol, BR-04044010 São Paulo, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Ciencias Biol, BR-04044010 São Paulo, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Ctr Terapia Celulare & Mol CTC Mol, BR-04044010 São Paulo, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Ciencias Biol, BR-04044010 São Paulo, SP, Brazil
dc.description.sponsorshipID FAPESP: 2013/16010-5
dc.identifier.file WOS000354374800001.pdf
dc.identifier.doi 10.3389/fimmu.2014.00309
dc.description.source Web of Science
dc.identifier.wos WOS:000354374800001



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