Emerging concepts about NAIP/NLIRC4 inflammasomes

Emerging concepts about NAIP/NLIRC4 inflammasomes

Author Lage, Silvia Lucena Autor UNIFESP Google Scholar
Longo, Carla Autor UNIFESP Google Scholar
Branco, Laura Migliari Autor UNIFESP Google Scholar
Costa, Thais Boccia da Autor UNIFESP Google Scholar
Buzzo, Carina de Lima Autor UNIFESP Google Scholar
Bortoluci, Karina Ramalho Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Neuronal apoptosis inhibitory protein (NAIP)/NOD-like receptor (NLR) containing a caspase activating and recruitment domain (CARD) 4 (NLRC4) inflammasome complexes are activated in response to proteins from virulent bacteria that reach the cell cytosol. Specific NAIP proteins bind to the agonists and then physically associate with NLRC4 to form an inflammasome complex able to recruit and activate pro-caspase-1. NAIP5 and NAIP6 sense flagellin, component of flagella from motile bacteria, whereas NAIP1 and NAIP2 detect needle and rod components from bacterial type III secretion systems, respectively. Active caspase-1 mediates the maturation and secretion of the pro-inflammatory cytokines, 11,113 and 11,18, and is responsible for the induction of pyroptosis, a pro-inflammatory form of cell death. in addition to these well-known effector mechanisms, novel roles have been described for NAIP/NLRC4 inflammasomes, such as phagosomal maturation, activation of inducible nitric oxide synthase, regulation of autophagy, secretion of inflammatory mediators, antibody production, activation of T cells, among others. These effector mechanisms mediated by NAIP/NLRC4 inflammasomes have been extensively studied in the context of resistance of infections and the potential of their agonists has been exploited in therapeutic strategies to non-infectious pathologies, such as tumor protection. Thus, this review will discuss current knowledge about the activation of NAIP/NLRC4 inflammasomes and their effector mechanisms.
Keywords NAIP
NLRC4
flagellin
caspase-1
inflammasomes
lysosomes
cell death
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
INCTV
Grant number FAPESP: 2013/16010-5
Date 2014-07-02
Published in Frontiers in Immunology. Lausanne: Frontiers Research Foundation, v. 5, 10 p., 2014.
ISSN 1664-3224 (Sherpa/Romeo, impact factor)
Publisher Frontiers Research Foundation
Extent 10
Origin http://dx.doi.org/10.3389/fimmu.2014.00309
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000354374800001
URI http://repositorio.unifesp.br/handle/11600/37983

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