Calcium Signaling Alterations, Oxidative Stress, and Autophagy in Aging

Calcium Signaling Alterations, Oxidative Stress, and Autophagy in Aging

Author Ureshino, Rodrigo Portes Autor UNIFESP Google Scholar
Rocha, Katiucha Karolina Autor UNIFESP Google Scholar
Lopes, Guiomar Silva Autor UNIFESP Google Scholar
Bincoletto, Claudia Autor UNIFESP Google Scholar
Smaili, Soraya Soubhi Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Significance: Aging is a multi-factorial process that may be associated with several functional and structural deficits which can evolve into degenerative diseases. in this review, we present data that may depict an expanded view of molecular aging theories, beginning with the idea that reactive oxygen species (ROS) are the major effectors in this process. in addition, we have correlated the importance of autophagy as a neuroprotective mechanism and discussed a link between age-related molecules, Ca2+ signaling, and oxidative stress. Recent Advances: There is evidence suggesting that alterations in Ca2+ homeostasis, including mitochondrial Ca2+ overload and alterations in electron transport chain (ETC) complexes, which increase cell vulnerability, are linked to oxidative stress in aging. As much as Ca2+ signaling is altered in aged cells, excess ROS can be produced due to an ineffective coupling of mitochondrial respiration. Damaged mitochondria might not be removed by the macroautophagic system, which is hampered in aging by lipofuscin accumulation, boosting ROS generation, damaging DNA, and, ultimately, leading to apoptosis. Critical Issues: This process can lead to altered protein expression (such as p53, Sirt1, and IGF-1) and progress to cell death. This cycle can lead to increased cell vulnerability in aging and contribute to an increased susceptibility to degenerative processes. Future Directions: A better understanding of Ca2+ signaling and molecular aging alterations is important for preventing apoptosis in age-related diseases. in addition, caloric restriction, resveratrol and autophagy modulation appear to be predominantly cytoprotective, and further studies of this process are promising in age-related disease therapeutics.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2014-07-01
Published in Antioxidants & Redox Signaling. New Rochelle: Mary Ann Liebert, Inc, v. 21, n. 1, p. 123-137, 2014.
ISSN 1523-0864 (Sherpa/Romeo, impact factor)
Publisher Mary Ann Liebert, Inc
Extent 123-137
Origin http://dx.doi.org/10.1089/ars.2013.5777
Access rights Closed access
Type Review
Web of Science ID WOS:000337225400010
URI http://repositorio.unifesp.br/handle/11600/37964

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