Soluble lutein in combination with brilliant blue as a new dye for chromovitrectomy

Soluble lutein in combination with brilliant blue as a new dye for chromovitrectomy

Author Badaro, Emmerson Autor UNIFESP Google Scholar
Furlani, Bruno Autor UNIFESP Google Scholar
Prazeres, Juliana Autor UNIFESP Google Scholar
Maia, Mauricio Autor UNIFESP Google Scholar
Souza Lima, Acacio Alves Autor UNIFESP Google Scholar
Sousa-Martins, Diogo Autor UNIFESP Google Scholar
Muccioli, Cristina Autor UNIFESP Google Scholar
Adami Lucatto, Luiz Filipe Autor UNIFESP Google Scholar
Belfort, Rubens Junior Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract A new dye for vitreoretinal surgery comprised of soluble lutein/zeaxanthin 1 % and brilliant blue 0.025 % is advantageous compared with other dyes currently used for chromovitrectomy, and showed no signs of toxicity at 1 month of follow-up.To evaluate the feasibility and safety of a dye [soluble lutein/zeaxanthin (LZ) 1 % and brilliant blue (BB) 0.025 %] for improving removal of vitreous, epiretinal membranes (ERM), and internal limiting membranes (ILM) in humans.We prospectively evaluated 18 eyes treated surgically for a macular hole or ERM. Eighteen surgeons performed chromovitrectomy using the dye, and completed a questionnaire to evaluate the efficacy and safety of the dye. . Examinations included best-corrected visual acuity and intraocular pressure measurements and optical coherence tomography, fluorescein angiography, and autofluorescence performed at baseline and days 1, 7, and 30 postoperatively.The green dye was deposited on the posterior pole; vigorous dye flushing into the vitreous cavity was unnecessary. All surgeons reported that the ILM stained greenish-blue; 94.4 % reported ILM peeling adequate; the ERM stained poorly. No evidence of toxicity was observed.The new dye deposited on the posterior pole due to its higher density. the ability to stain the ILM was similar to BB. the new dye has ability to stain the vitreous, hyaloid, and especially the ILM satisfactorily. the new dye may be useful during chromovitrectomy.
Keywords Chromovitrectomy
Internal limiting membrane
Lutein
Macular hole
Vitreoretinal surgery
Zeaxanthin
Language English
Sponsor Kemin Inc., Des Moines, IA, USA
Date 2014-07-01
Published in Graefes Archive for Clinical and Experimental Ophthalmology. New York: Springer, v. 252, n. 7, p. 1071-1078, 2014.
ISSN 0721-832X (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 1071-1078
Origin http://dx.doi.org/10.1007/s00417-013-2539-5
Access rights Closed access
Type Article
Web of Science ID WOS:000338492500007
URI http://repositorio.unifesp.br/handle/11600/37925

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