Do patients with juvenile idiopathic arthritis in remission exhibit active synovitis on joint ultrasound?

Show simple item record

dc.contributor.author Miotto e Silva, Vanessa Bugni [UNIFESP]
dc.contributor.author Tavares da Silva, Carolina de Freitas [UNIFESP]
dc.contributor.author Vilela Mitraud, Sonia de Aguiar [UNIFESP]
dc.contributor.author Vilar Furtado, Rita Nely [UNIFESP]
dc.contributor.author Esteves Hilario, Maria Odete [UNIFESP]
dc.contributor.author Natour, Jamil [UNIFESP]
dc.contributor.author Terreri, Maria Teresa [UNIFESP]
dc.date.accessioned 2016-01-24T14:37:31Z
dc.date.available 2016-01-24T14:37:31Z
dc.date.issued 2014-07-01
dc.identifier http://dx.doi.org/10.1007/s00296-013-2909-7
dc.identifier.citation Rheumatology International. Heidelberg: Springer Heidelberg, v. 34, n. 7, p. 937-945, 2014.
dc.identifier.issn 0172-8172
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/37923
dc.description.abstract The aim of the study was to assess the presence and characteristics of subclinical synovitis using power Doppler (PD) ultrasonography on patients with juvenile idiopathic arthritis (JIA) in clinical remission and compare the findings with those of healthy children. A cross-sectional study was carried out involving the clinical (physical exam, functional capacity and laboratory tests) and ultrasonography evaluation of 34 joints (synovial fluid/hypertrophy, PD signal and bone erosion). Subclinical synovitis was defined as the presence of synovial hypertrophy/joint effusion with or without any PD signal. Thirty-six patients (11.5 +/- A 3.74 years) and 36 controls (sex and age matched) were evaluated (2,448 joints). Twenty-seven patients were in remission on medication (mean duration: 1.8 +/- A 2.2 years). Subclinical synovitis was detected in 41.7 % patients and 11.1 % controls (p = 0.003). Erosion was detected in three patients (8.3 %). Subclinical synovitis was found in 38/1,224 (3.1 %) joints in the patients (most affected: radiocarpal wrist, anterior elbow and tibiotalar ankle) and 8/1,224 (0.6 %) joints in the controls (most affected: radiocarpal wrist). Differences in subclinical synovitis between patients and controls were found in the elbows (p = 0.033) and ankles (p = 0.006). A greater frequency of subclinical synovitis was found in patients with the extended oligoarticular or polyarticular subtypes (p = 0.013), those at an older age at disease onset (p = 0.007) and using methotrexate (p = 0.049). Patients with JIA in remission exhibit subclinical synovitis more frequently than controls. Subclinical synovitis was more frequent in patients with the polyarticular involvement and those at an older age at disease onset. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 937-945
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Rheumatology International
dc.rights Acesso restrito
dc.subject Juvenile idiopathic arthritis en
dc.subject Synovitis en
dc.subject Doppler ultrasound en
dc.subject Child en
dc.subject Remission induction en
dc.title Do patients with juvenile idiopathic arthritis in remission exhibit active synovitis on joint ultrasound? en
dc.type Artigo
dc.rights.license http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Dept Pediat, Pediat Rheumatol Unit,Allergy Immunol & Rheumatol, BR-04022005 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, BR-04022005 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Dept Diagnost Imaging, BR-04022005 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Dept Med, Div Rheumatol, BR-04022005 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Dept Pediat, Pediat Rheumatol Unit,Allergy Immunol & Rheumatol, BR-04022005 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, BR-04022005 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Dept Diagnost Imaging, BR-04022005 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Dept Med, Div Rheumatol, BR-04022005 São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2010/50128-5
dc.identifier.doi 10.1007/s00296-013-2909-7
dc.description.source Web of Science
dc.identifier.wos WOS:000338332300006



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account