Biocompatibility of a porous alumina ceramic scaffold coated with hydroxyapatite and bioglass

Biocompatibility of a porous alumina ceramic scaffold coated with hydroxyapatite and bioglass

Author Kido, Hueliton Wilian Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Oliveira, Poliani de Google Scholar
Parizotto, Nivaldo Antonio Google Scholar
Camilo, Claudia Cristiane Google Scholar
Fortulan, Carlos Alberto Google Scholar
Marcantonio, Elcio Google Scholar
Pereira da Silva, Victor Hugo Autor UNIFESP Google Scholar
Muniz Renno, Ana Claudia Autor UNIFESP Google Scholar
Institution Universidade Federal de São Carlos (UFSCar)
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
São Paulo State Univ UNESP
Abstract This study aimed to evaluate the osteointegration and genotoxic potential of a bioactive scaffold, composed of alumina and coated with hydroxyapatite and bioglass, after their implantation in tibias of rats. for this purpose, Wistar rats underwent surgery to induce a tibial bone defect, which was filled with the bioactive scaffolds. Histology analysis (descriptive and morphometry) of the bone tissue and the single-cell gel assay (comet) in multiple organs (blood, liver, and kidney) were used to reach this aim after a period of 30, 60, 90, and 180 days of material implantation. the main findings showed that the incorporation of hydroxyapatite and bioglass in the alumina scaffolds produced a suitable environment for bone ingrowth in the tibial defects and did not demonstrate any genotoxicity in the organs evaluated in all experimental periods. These results clearly indicate that the bioactive scaffolds used in this study present osteogenic potential and still exhibit local and systemic biocompatibility. These findings are promising once they convey important information about the behavior of this novel biomaterial in biological system and highlight its possible clinical application. (C) 2013 Wiley Periodicals, Inc.
Keywords alumina
DNA damage
bone repair
Language English
Date 2014-07-01
Published in Journal of Biomedical Materials Research Part A. Hoboken: Wiley-Blackwell, v. 102, n. 7, p. 2072-2078, 2014.
ISSN 1549-3296 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 2072-2078
Access rights Closed access
Type Article
Web of Science ID WOS:000337570400002

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