Identifying Gene-Environment Interactions in Schizophrenia: Contemporary Challenges for Integrated, Large-scale Investigations

Identifying Gene-Environment Interactions in Schizophrenia: Contemporary Challenges for Integrated, Large-scale Investigations

Author van Os, Jim Google Scholar
Rutten, Bart P. Google Scholar
Myin-Germeys, Inez Google Scholar
Delespaul, Philippe Google Scholar
Viechtbauer, Wolfgang Google Scholar
van Zelst, Catherine Google Scholar
Bruggeman, Richard Google Scholar
Reininghaus, Ulrich Google Scholar
Morgan, Craig Google Scholar
Murray, Robin M. Google Scholar
Di Forti, Marta Google Scholar
McGuire, Philip Google Scholar
Valmaggia, Lucia R. Google Scholar
Kempton, Matthew J. Google Scholar
Gayer-Anderson, Charlotte Google Scholar
Hubbard, Kathryn Google Scholar
Beards, Stephanie Google Scholar
Stilo, Simona A. Google Scholar
Onyejiaka, Adanna Google Scholar
Bourque, Francois Google Scholar
Modinos, Gemma Google Scholar
Tognin, Stefania Google Scholar
Calem, Maria Google Scholar
O'Donovan, Michael C. Google Scholar
Owen, Michael J. Google Scholar
Holmans, Peter Google Scholar
Williams, Nigel Google Scholar
Craddock, Nicholas Google Scholar
Richards, Alexander Google Scholar
Humphreys, Isla Google Scholar
Meyer-Lindenberg, Andreas Google Scholar
Leweke, F. Markus Google Scholar
Tost, Heike Google Scholar
Akdeniz, Ceren Google Scholar
Rohleder, Cathrin Google Scholar
Bumb, J. Malte Google Scholar
Schwarz, Emanuel Google Scholar
Alptekin, Koksal Google Scholar
Ucok, Alp Google Scholar
Saka, Meram Can Google Scholar
Atbasoglu, E. Cem Google Scholar
Guloksuz, Sinan Google Scholar
Gumus-Akay, Guvem Google Scholar
Cihan, Burin Google Scholar
Karadag, Hasan Google Scholar
Soygur, Haldan Google Scholar
Cankurtaran, Eylem Sahin Google Scholar
Ulusoy, Semra Google Scholar
Akdede, Berna Google Scholar
Binbay, Tolga Google Scholar
Ayer, Ahmet Google Scholar
Noyan, Handan Google Scholar
Karadayi, Gulsah Google Scholar
Akturan, Elin Google Scholar
Ulas, Halis Google Scholar
Arango, Celso Google Scholar
Parellada, Mara Google Scholar
Bernardo, Miguel Google Scholar
Sanjuan, Julio Google Scholar
Bobes, Julio Google Scholar
Arrojo, Manuel Google Scholar
Luis Santos, Jose Google Scholar
Cuadrado, Pedro Google Scholar
Rodriguez Solano, Jose Juan Google Scholar
Carracedo, Angel Google Scholar
Garcia Bernardo, Enrique Google Scholar
Roldan, Laura Google Scholar
Lopez, Gonzalo Google Scholar
Cabrera, Bibiana Google Scholar
Cruz, Sabrina Google Scholar
Diaz Mesa, Eva Ma Google Scholar
Pouso, Maria Google Scholar
Jimenez, Estela Google Scholar
Sanchez, Teresa Google Scholar
Rapado, Marta Google Scholar
Gonzalez, Emiliano Google Scholar
Martinez, Covadonga Google Scholar
Sanchez, Emilio Google Scholar
Soledad Olmeda, Ma Google Scholar
Haan, Lieuwe de Google Scholar
Velthorst, Eva Google Scholar
van der Gaag, Mark Google Scholar
Selten, Jean-Paul Google Scholar
van Dam, Daniella Google Scholar
van der Ven, Elsje Google Scholar
van der Meer, Floor Google Scholar
Messchaert, Elles Google Scholar
Kraan, Tamar Google Scholar
Burger, Nadine Google Scholar
Leboyer, Marion Google Scholar
Szoke, Andrei Google Scholar
Schurhoff, Franck Google Scholar
Llorca, Pierre-Michel Google Scholar
Jamain, Stephane Google Scholar
Tortelli, Andrea Google Scholar
Frijda, Flora Google Scholar
Vilain, Jeanne Google Scholar
Galliot, Anne-Marie Google Scholar
Baudin, Gregoire Google Scholar
Ferchiou, Aziz Google Scholar
Richard, Jean-Romain Google Scholar
Bulzacka, Ewa Google Scholar
Charpeaud, Thomas Google Scholar
Tronche, Anne-Marie Google Scholar
De Hert, Marc Google Scholar
van Winkel, Ruud Google Scholar
Decoster, Jeroen Google Scholar
Derom, Catherine Google Scholar
Thiery, Evert Google Scholar
Stefanis, Nikos C. Google Scholar
Sachs, Gabriele Google Scholar
Aschauer, Harald Google Scholar
Lasser, Iris Google Scholar
Winklbaur, Bernadette Google Scholar
Schlogelhofer, Monika Google Scholar
Riecher-Rossler, Anita Google Scholar
Borgwardt, Stefan Google Scholar
Walter, Anna Google Scholar
Harrisberger, Fabienne Google Scholar
Smieskova, Renata Google Scholar
Rapp, Charlotte Google Scholar
Ittig, Sarah Google Scholar
Soguel-Dit-Piquard, Fabienne Google Scholar
Studerus, Erich Google Scholar
Klosterkotter, Joachim Google Scholar
Ruhrmann, Stephan Google Scholar
Paruch, Julia Google Scholar
Julkowski, Dominika Google Scholar
Hilboll, Desiree Google Scholar
Sham, Pak C. Google Scholar
Cherny, Stacey S. Google Scholar
Chen, Eric Y. H. Google Scholar
Campbell, Desmond D. Google Scholar
Li, Miaoxin Google Scholar
Maria Romeo-Casabona, Carlos Google Scholar
Emaldi Cirion, Aitziber Google Scholar
Urruela Mora, Asier Google Scholar
Jones, Peter Google Scholar
Kirkbride, James Google Scholar
Cannon, Mary Google Scholar
Rujescu, Dan Google Scholar
Tarricone, Ilaria Google Scholar
Berardi, Domenico Google Scholar
Bonora, Elena Google Scholar
Seri, Marco Google Scholar
Marcacci, Thomas Google Scholar
Chiri, Luigi Google Scholar
Chierzi, Federico Google Scholar
Storbini, Viviana Google Scholar
Braca, Mauro Google Scholar
Minenna, Maria Gabriella Google Scholar
Donegani, Ivonne Google Scholar
Fioritti, Angelo Google Scholar
La Barbera, Daniele Google Scholar
La Cascia, Caterina Erika Google Scholar
Mule, Alice Google Scholar
Sideli, Lucia Google Scholar
Sartorio, Rachele Google Scholar
Ferraro, Laura Google Scholar
Tripoli, Giada Google Scholar
Seminerio, Fabio Google Scholar
Marinaro, Anna Maria Google Scholar
McGorry, Patrick Google Scholar
Nelson, Barnaby Google Scholar
Amminger, G. Paul Google Scholar
Pantelis, Christos Google Scholar
Menezes, Paulo R. Google Scholar
Del-Ben, Cristina M. Google Scholar
Tenan, Silvia H. Gallo Google Scholar
Shuhama, Rosana Google Scholar
Ruggeri, Mirella Google Scholar
Tosato, Sarah Google Scholar
Lasalvia, Antonio Google Scholar
Bonetto, Chiara Google Scholar
Ira, Elisa Google Scholar
Nordentoft, Merete Google Scholar
Krebs, Marie-Odile Google Scholar
Barrantes-Vidal, Neus Google Scholar
Cristobal, Paula Google Scholar
Kwapil, Thomas R. Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Bressan, Rodrigo A. Autor UNIFESP Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Maric, Nadja P. Google Scholar
Andric, Sanja Google Scholar
Mihaljevic, Marina Google Scholar
Mirjanic, Tijana Google Scholar
European Network Natl Google Scholar
Institution Maastricht Univ
Kings Coll London
Mondriaan Mental Hlth Trust
Univ Groningen
Cardiff Univ
Cent Inst Mental Hlth
Dokuz Eylul Univ
Istanbul Univ
Ankara Univ
Yale Univ
Middle E Tech Univ
Diskapi YB Res & Training Hosp
Turkish Federat Schizophrenia Assoc
Ataturk Training & Res Hosp
Manisa Mental Hlth Hosp
Univ Complutense
Univ Barcelona
Univ Valencia
Univ Oviedo
Univ Santiago de Compostela
Hosp Virgen de la Luz
Hosp Univ Infanta Leonor Hosp Virgen Torre
Hosp Clin Univ
Hosp Psiquiatr Conxo
Univ Amsterdam
Vrije Univ Amsterdam
EMGO Inst Hlth & Care Res
Parnassia Psychiat Inst
Rivierduinen Psychiat Inst
Grp Hosp Mondor
Hop Henri Mondor
Univ Paris Est
Fdn Fondamental
CMP B CHU
Univ Auvergne
EPS Maison Blanche
UPC KU Leuven
UPC
Katholieke Univ Leuven
Assoc Sci Res Multiple Births
Univ Ghent
Univ Athens
Med Univ Vienna
Psychiat Univ Clin Basel
Univ Cologne
Univ Hong Kong
Univ Basque Country
Univ Zaragoza
Univ Cambridge
UCL
Royal Coll Surgeons Ireland
Univ Munich
Univ Bologna
Local Hlth Trust
Univ Palermo
P Giaccone Gen Hosp
Univ Melbourne
Universidade de São Paulo (USP)
Univ Verona
Copenhagen Univ Hosp
Univ Paris 05
Univ Autonoma Barcelona
St Pere Claver Fundacio Sanitaria
Univ N Carolina
CIBERSAM
Universidade Federal de São Paulo (UNIFESP)
Univ Belgrade
Abstract Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G x E), however, so far, thorough replication of findings is rare and G x E research still faces several conceptual and methodological challenges. in this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G x E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G x E in schizophrenia. While such investigations are now well underway, new challenges emerge for G x E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype.
Keywords schizophrenia
gene-environment interaction
psychosis
epidemiology
genetics
Language English
Sponsor European Community
Grant number European Community: HEALTH-F2-2009-241909
Date 2014-07-01
Published in Schizophrenia Bulletin. Oxford: Oxford Univ Press, v. 40, n. 4, p. 729-736, 2014.
ISSN 0586-7614 (Sherpa/Romeo, impact factor)
Publisher Oxford Univ Press
Extent 729-736
Origin http://dx.doi.org/10.1093/schbul/sbu069
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000338130300004
URI http://repositorio.unifesp.br/handle/11600/37894

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