Radiochemical pharmacokinetic profile of P10 peptide with antifungal properties

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dc.contributor.author Faintuch, Bluma L.
dc.contributor.author Oliveira, Erica A.
dc.contributor.author Munoz, Julian E.
dc.contributor.author Travassos, Luiz R. [UNIFESP]
dc.contributor.author Taborda, Carlos Pelleschi [UNIFESP]
dc.date.accessioned 2016-01-24T14:37:28Z
dc.date.available 2016-01-24T14:37:28Z
dc.date.issued 2014-07-01
dc.identifier http://dx.doi.org/10.1093/mmy/myu024
dc.identifier.citation Medical Mycology. London: Informa Healthcare, v. 52, n. 5, p. 544-548, 2014.
dc.identifier.issn 1369-3786
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/37890
dc.description.abstract Paracoccidioidomycosis (PCM) is a chronic granulomatous disease that is caused by the thermally dimorphic fungus Paracoccidioides brasiliensis. It is endemic in some countries of Latin America and can cause a high-burden fungal infection with significant morbidity and mortality. the peptide P10, which demonstrates immune protection against experimental PCM, was radiolabeled with a radioisotope and evaluated in vivo. the radiolabeling was conducted to trace the pharmacokinetics of the molecule in principal organs and tissues. This was achieved with high radiochemical purity. Biodistribution and scintigraphic imaging showed fast blood clearance that was mainly renal; however, hepatobiliar excretion was also, with marked uptake in cervical lymph nodes. This profile may be useful for the development of a prophylactic drug or vaccine for patients exposed to PCM. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 544-548
dc.language.iso eng
dc.publisher Informa Healthcare
dc.relation.ispartof Medical Mycology
dc.rights Acesso aberto
dc.subject P10 peptide en
dc.subject P. brasiliensis en
dc.subject radiolabeling en
dc.subject biodistribution evaluation en
dc.title Radiochemical pharmacokinetic profile of P10 peptide with antifungal properties en
dc.type Artigo
dc.rights.license http://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.contributor.institution Inst Energy & Nucl Res
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Inst Energy & Nucl Res, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Dept Microbiol, Inst Biomed Sci, BR-05508 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Lab Med Mycol, Inst Med Trop São Paulo, IMTSP Lab Invest Med 53,LIM 53, BR-05508 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2011/17267-4
dc.identifier.doi 10.1093/mmy/myu024
dc.description.source Web of Science
dc.identifier.wos WOS:000339914400012



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